DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9698 and CG15864

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	158/517 - (30%)
Similarity:	247/517 - (47%)	Gaps:	85/517 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNEAREWGPSYFESPINKY 89
            :.:|..|:.|:...|.::|.:::.::...:.|.:.::..|.:...|..|.:....||..:|:|.:
  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96

  Fly    90 LLNKRLTVDWQ-------RVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAIDGLLRLQYVY 147
            .|..||...|:       :|||   .:.|.....||.    |:.:|...:|:.|..|:..|...|
  Fly    97 RLIHRLHTSWRKWYQYAIKVEN---NALGHIENARLM----RKMLPTSSDLQQACRGIHDLMSFY 154

  Fly   148 RLKAKDLARGILDGVDY-GTQLNSEHCVDIARLALRDQHPRLAHSW----LIEANDRLTGGEKEE 207
            .||.::||.|.|.|... ||.|.:..|:.:...:::.:...||.:|    ||...::.     ::
  Fly   155 DLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFENKF-----DK 214

  Fly   208 QLKPQILALLVQAKKELED-FRGLNDTYQELIGIQSASEE--HAKNYETFLNALSEKALLNESKP 269
            ....:...||:...|:|.| |....:..:.:|    ||.|  |      |...||.|.
  Fly   215 YRVHKAWGLLLAKNKQLTDAFYHFENKPEGII----ASNEVIH------FKEELSTKQ------- 262

  Fly   270 ILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKEQRHLRCGYVTETHPFLWIAPLKAEELFQDPL 334
                                  .|:    :..::...|.|.|.|.|.||..|||||.|||..||.
  Fly   263 ----------------------NCA----VVVQKPSRLHCRYNTTTTPFTRIAPLKMEELGLDPY 301

  Fly   335 LVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESVVSNVRTSQFTFIPVTAHKVLSTIDQRVAD 399
            :|::|||||.:|||.:...:...|   ::|...:.  |.||||:.::| |.|    .|:::||.|
  Fly   302 MVVFHDVIYDTEIDGMLNSSNFGL---SLTDSGQK--SEVRTSKDSYI-VDA----KTLNERVTD 356

  Fly   400 MTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSSPEMGNRIATVLFYLSDVAQGGGT 464
            ||..:|:.::.....|||:||||..|.|:...|.     .:.|:.|:|||||||||.:|..||.|
  Fly   357 MTGFSMEMSDPFSLINYGLGGHYMLHYDFHEYTN-----TTRPKQGDRIATVLFYLGEVDSGGAT 416

  Fly   465 AFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAGSKWVQNRWIRENDQSDRRPC 526
            .||.:...:.|||.:|.||:|||.||..::::.|.|||:|:|||:|..:||.|..|....||
  Fly   417 IFPMINITVTPKKGSAVFWYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPC 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	35/137 (26%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	68/170 (40%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	35/137 (26%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	28/111 (25%)
		P4Hc	313..467	CDD:214780	67/168 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461860
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900