DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and p4ha2

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	530	Identity:	156/530 - (29%)
Similarity:	256/530 - (48%)	Gaps:	43/530 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNEAREWGPSYFESPINK 88
            |.|:|..:||.:...|:.::..:::::.:.:::|..:|....|.:...:.:......|...|:|.
Frog    22 EVFTSTGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSRSTADPEGYLGHPVNA 86

  Fly    89 YLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAIDGLLRLQYVYRLKAKD 153
            |.|.||...||..:|||:...:.:..:... .|: ||..|.:::..||...|:|:|..|:|....
Frog    87 YKLVKRFNTDWSSLENLVLQDSAKGFIANF-TFQ-REYFPTEEDETGAARALMRIQDTYKLDPDV 149

  Fly   154 LARGILDGVDYGTQLNSEHCVDIARLALRD---QHPRLAHSWLIEANDRLTGGEKEEQLKPQILA 215
            :|:|.|.|.:|.:.|:::....:.::|..|   .|..|   |:.:|..::..||.....|..:|.
Frog   150 IAKGKLPGTNYISSLSADDSFGMGKIAYHDGDYYHTVL---WMQQALKQMDEGEDAVVNKVDVLD 211

  Fly   216 LLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFLNALSEKALL----NES--------K 268
            .|.....:|.|.....:..:.|:.: ..:.:.|.|...:...:.||...    |||        :
Frog   212 YLSYTVFQLGDVPRALELTKRLLAL-DPNHDRAVNNLKYFEKMQEKQKAELKQNESTNTESATRQ 275

  Fly   269 PILEHAPIPEEGEPVGEFQAYSLTCSGHW-RLTPKEQRHLRCGYVT-ETHPFLWIAPLKAEELFQ 331
            |.:...|:    :.:.|...|...|.|.. ::.|:.||.|.|.|.. ...|:|.::|:|.|:.:.
Frog   276 PGVYSRPL----DYLPERDVYEALCRGEGVKMNPRRQRRLFCRYHNGNRSPYLILSPVKVEDEWD 336

  Fly   332 DPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESV--VSNVRTSQFTFIPVTAHKVLSTID 394
            .|.:|.|.:.:...||..|::|.:.:|.|||:......|  |:|.|.|:..::......|::.::
Frog   337 SPRIVRYLNALSDEEIAKIKELAKPKLARATVRDPKTGVLSVANYRVSKSAWLEENDDPVIARVN 401

  Fly   395 QRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSSPEM------GNRIATVLF 453
            .|:..:|.|.:..||..|.||||:||.|..|        ||......|::      |||:||.|.
Frog   402 LRMQAITGLTVDTAELLQVANYGMGGQYEPH--------FDFSRKDEPDVFKRLGTGNRVATFLN 458

  Fly   454 YLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAGSKWVQNRWIREN 518
            |:|||..||.|.||.....:.|||..|.||:||..||.||.||:|.|||::.|||||.|:|..|.
Frog   459 YMSDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWFHER 523

  Fly   519 DQSDRRPCEL 528
            .|...|||.|
Frog   524 GQEFLRPCGL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	32/130 (25%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	71/178 (40%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	18/85 (21%)
		TPR repeat	166..201	CDD:276809	7/37 (19%)
		TPR repeat	206..236	CDD:276809	6/29 (21%)
		P4Hc	348..521	CDD:214780	71/180 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010