DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and PH4alphaNE2

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	154/537 - (28%)
Similarity:	249/537 - (46%)	Gaps:	45/537 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LFLLFHQAIPSVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNE 73
            |.|.|.|...:.:...|..|:..|..:...|..:|.:::|.......|...:|..:.:....|.|
  Fly    14 LSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKMMKRRQE 78

  Fly    74 AREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPL----TRLRKFRNRETMPDKKELE 134
            .:. ....|.:||:.:.|.:.:..:|......:.|..|::.|    :|:      ..:|...:..
  Fly    79 YKS-SMEIFANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRM------PLLPKYFDFI 136

  Fly   135 GAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWL---IEA 196
            .|.:|:.::|..|::.:.|:|:|:||||.|.:.|....|:.|....:.:.....|..|:   |||
  Fly   137 DAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEA 201

  Fly   197 NDRLTGGEKEEQLKPQILA----LLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFLNA 257
            .|:.:.....|.|:...||    :|.|.:.:..:..|....||..:.:.....|..:.|.
  Fly   202 YDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYR----- 261

  Fly   258 LSEKALLNESKPILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKEQRHLRCGYVTETHPFLWIA 322
            :.||..|..|    :..||.::.:...|.......|||..:: |:...:|.|.|...|.|||.:|
  Fly   262 ILEKRDLTLS----DIEPIEQDKDNSHERLVLPPCCSGRCQV-PRNLSNLYCVYNHVTSPFLQLA 321

  Fly   323 PLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATIT----SHNESVVSNVRTSQFTFIP 383
            |:|.|.|..||.:||.||:|.|.|..:||..::..::.:..|    |.:|:.|...|||:..:..
  Fly   322 PIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYS 386

  Fly   384 VTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSSPEMGN-- 446
            ...:.....|.:|:.|.|.|:|...|.:|..|||:||.:..|:|.         |:|.....|
  Fly   387 SDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDM---------LLSEKNRFNGT 442

  Fly   447 --RIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAGSKW 509
              ||||.||||::|.|||||.||:|...:.|:..:|.||:||...|...:.:.|..||:|.||||
  Fly   443 SDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKW 507

  Fly   510 VQNRWIRENDQSDRRPC 526
            |.::||.:..|...|||
  Fly   508 VMSKWINDMGQEFTRPC 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	26/134 (19%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	62/178 (35%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	26/134 (19%)
		TPR repeat	175..200	CDD:276809	4/24 (17%)
		TPR_16	176..254	CDD:290168	16/77 (21%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		TPR_2	220..253	CDD:285020	6/32 (19%)
		P4Hc	342..513	CDD:214780	62/179 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461862
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910