DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and p4ha2

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	543	Identity:	161/543 - (29%)
Similarity:	271/543 - (49%)	Gaps:	31/543 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VLFLLFHQAIPSVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERN 72
            ::|||...:..|.:..|.|:||.:||.:...|:::|..:::::...:.||:.:::...:.:....
Zfish     5 LVFLLSTLSFSSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLDKLTR 69

  Fly    73 EAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAI 137
            .:......:...|:|.|.|.|||..:|..:|:|:.....:..::.:..  :|:..||:::.:||.
Zfish    70 TSTSDPEGFLAHPVNAYKLMKRLNTEWSELESLVLQDPSDGFISNMSV--HRQYFPDEEDEKGAA 132

  Fly   138 DGLLRLQYVYRLKAKDLARGIL------DGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWLIEA 196
            ..|||||..|:|.|:..::|.|      .||.|...|..:.|.|:.::|..|.....:..|:.::
Zfish   133 KALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVLWMQQS 197

  Fly   197 NDRLTGGEKEEQLKPQILALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFLNALSEK 261
            ..::..||:.:..|..:|..|..:..::.|.....:..:.|:.|..:.:....|...|     |:
Zfish   198 LRQMDSGEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYF-----ER 257

  Fly   262 ALLNESKPILEHAPIPEEGEPV------------GEFQAYSLTCSGHW-RLTPKEQRHLRCGYVT 313
            .|..|.:...:..|.|.:..|:            .|.:||...|.|.. ::|.|.|..|.|.|..
Zfish   258 LLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSRLFCRYRD 322

  Fly   314 -ETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESV--VSNVR 375
             ..:|.|.:.|:|.|:.:..|.:|.:.:.:...||..|:::...:|.|||:......|  |::.|
Zfish   323 GNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGVLTVAHYR 387

  Fly   376 TSQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVS 440
            .|:..::......|::.::||:.|:|.|.:..||..|.||||:||.|..|.|:..:...||  ..
Zfish   388 VSKSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSRKDEPDA--FK 450

  Fly   441 SPEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIA 505
            |...|||:||.|.|:|||..||.|.||.....:.|:|..|.||:||..||.||.||:|.|||::.
Zfish   451 SLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTRHAACPVLV 515

  Fly   506 GSKWVQNRWIRENDQSDRRPCEL 528
            |||||.|:||.|..|..||||.|
Zfish   516 GSKWVSNKWIHERGQEFRRPCGL 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	32/130 (25%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	71/172 (41%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	32/130 (25%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	71/174 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820