DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and P4ha2

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	166/523 - (31%)
Similarity:	255/523 - (48%)	Gaps:	35/523 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNEAREWGPSYFESPINK 88
            |||:||..||.:...|:.:|..:::::...:.||..:|:...:.|...:::......|...|:|.
  Rat    22 EFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNA 86

  Fly    89 YLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAIDGLLRLQYVYRLKAKD 153
            |.|.|||..||..:.:|:........:..|..  .|:..|..::..||...|:|||..|:|....
  Rat    87 YKLVKRLNTDWPALGDLVLQDAAAGFVANLSV--QRQFFPTDEDESGAARALMRLQDTYKLDPDM 149

  Fly   154 LARGILDGVDYGTQLNSEHCVDIARLALRD---QHPRLAHSWLIEANDRLTGGEKEEQLKPQILA 215
            ::||.|.|..|...|:.:.|..:.|.|..:   .|..|   |:.:...:|..||:....|..:|.
  Rat   150 ISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVL---WMEQVLKQLDAGEEATVTKSLVLD 211

  Fly   216 LLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFLNALSE---KALLNE------SKPIL 271
            .|..|..:|.|.....:..:.|:.:..:.|....|...|...|.|   |:|.|:      |:..|
  Rat   212 YLSYAVFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERLLEEERGKSLSNQTDAGLASQENL 276

  Fly   272 EHAPIPEEGEPVGEFQAYSLTCSGHW-RLTPKEQRHLRCGYVTETH-----PFLWIAPLKAEELF 330
            ...|:    :.:.|...|...|.|.. ::||:.|:.|.|.|    |     |.|.|||.|.|:.:
  Rat   277 YERPV----DYLPERDVYESLCRGEGIKMTPRRQKRLFCRY----HHGNRVPQLLIAPFKEEDEW 333

  Fly   331 QDPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESV--VSNVRTSQFTFIPVTAHKVLSTI 393
            ..|.:|.|:||:...||:.|:::.:.:|.|||:......|  |::.|.|:.:::......|::.:
  Rat   334 DSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARV 398

  Fly   394 DQRVADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSSPEMGNRIATVLFYLSDV 458
            ::|:..:|.|.:|.||..|.||||:||.|..|.|:......||  ......|||:||.|.|:|||
  Rat   399 NRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDA--FKRLGTGNRVATFLNYMSDV 461

  Fly   459 AQGGGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVRTQHGACPIIAGSKWVQNRWIRENDQSDR 523
            ..||.|.||.|...:.|||..|.||:||..||.||.||:|.|||::.|.|||.|:|..|..|...
  Rat   462 EAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFL 526

  Fly   524 RPC 526
            |||
  Rat   527 RPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	34/130 (26%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	70/172 (41%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	19/76 (25%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	70/174 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820