DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9698 and PH4alphaNE3

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	134/518 - (25%)
Similarity:	228/518 - (44%)	Gaps:	74/518 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNEAREWGPSYFESPINK 88
            ||..:......:...:.:::.::..:.....:|...||...:|.....:.|:.....|..:|::.
  Fly    16 EFLDTESAKMDLMQLDVELIDNLMNYAEKIDEKASQLKRLAQELRQPLHSAKGREEEYLGNPLHS 80

  Fly    89 YLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAIDGLLRLQYVYRLKAKD 153
            :.|.:.:..||:.:|..|....||:.:..||  |....:|.:.:.|.|...:.|:...|.:...|
  Fly    81 FPLIRHMYQDWRYLEEFMKKPVGEEEIQFLR--RKLPELPWQVDTEEASVSIFRIAETYGMMPWD 143

  Fly   154 LARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWLIEANDRLTGGEKEEQ--------LK 210
            :|.|::|.|.:.:.|.:..|.::|::..:..:.:.|..|:..:..|:    |||.        :.
  Fly   144 MANGLIDNVRFNSTLPALDCFEVAKMYFKWGYFKQALQWITISKARM----KEEYSGVYEVLGMN 204

  Fly   211 PQILALLVQAKKELEDFRGLNDTYQELIGIQSASEEHAKNYETFL-------NALSEKALLNESK 268
            .|.:||| ||:.              |:.:....|.|    |..|       |::|   ||::.|
  Fly   205 RQDVALL-QARC--------------LVELDRRDEAH----EVLLDQPDLADNSIS---LLDQFK 247

  Fly   269 --PILEHAPIPEEGEPVGEFQAYSLTCSGHWRLTPKEQRHLRCGYVTETHPFLWIAPLKAEELFQ 331
              |.......|:.||      .|...|...:...|.:   |.|.|.:.|..||.:||||.||:..
  Fly   248 ANPYEAIDSSPKLGE------GYKRLCRSSFSPNPSK---LHCRYNSTTSAFLILAPLKMEEISL 303

  Fly   332 DPLLVLYHDVIYQSEIDVIRKLTENRLMRATITSHNESVVSNVRTSQFTFIPVTAHKVLSTIDQR 396
            :|.:|:|||::...:|..:..|.|..|....:...|:   :..|:|..|  |: ...:|.::.||
  Fly   304 EPHIVVYHDILPDKDIQQLITLAEPLLKPTEMFDDNK---NEARSSYRT--PL-GGPLLDSLTQR 362

  Fly   397 VADMTNLNMKYAEDHQFANYGIGGHYGQHMDWFYQTTFDAGLVSSPEMGNRIATVLFYLSDVAQG 461
            :.|:|.|.::.........||.|..|..:.|:|.:...:     |...|:|:||.:|||:|...|
  Fly   363 MRDITGLQIRQGNPINIIKYGFGAPYTNYYDFFKKRNSE-----SKGFGDRMATFMFYLNDAPYG 422

  Fly   462 GGTAFPQLRTLLKPKKYAAAFWHNLHASGVGDVR-----TQHGACPIIAGSKWVQNRWIREND 519
            |.|.||:|...:..::....||:||:    ||..     |.|.|||:..|||||...||.|.|
  Fly   423 GATVFPRLNVKVPAERGKVLFWYNLN----GDTHDMEPTTMHAACPVFHGSKWVMTAWIHEYD 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	25/130 (19%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	53/175 (30%)
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	25/125 (20%)
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	53/176 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461876
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910