DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9698 and P4ha3

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	XP_006508007.1	Gene:	P4ha3 / 320452	MGIID:	2444049	Length:	551	Species:	Mus musculus

Alignment Length:	568	Identity:	160/568 - (28%)
Similarity:	247/568 - (43%)	Gaps:	118/568 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARLREFENERNEAREWGPSYFE------- 83
            ||::..:.:....|::::..::::|...:       ||||:.....::..    |..|
Mouse    29 FSALTSVARALAPERRLLGTLRRYLRGEE-------ARLRDLTRFYDKVL----SLHEDLKIPVV 82

  Fly    84 SPINKYLLNKRLTVDWQRV-------ENLMATSTGEKPLTRLRKFRNRETMPDKKELEGAIDGLL 141
            :|:..:.|.|||..||:.|       ||:.|...|.:.:        .:.:|..::||||...|:
Mouse    83 NPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKV--------EQDLPAFEDLEGAARALM 139

  Fly   142 RLQYVYRLKAKDLARGILDGVDYGT-----------QLNSEHCVDIARLALRDQHPRLAHS---- 191
            |||.||.|..|.||||:...|...:           .|.::.|..:.:.:...:..::|:.
Mouse   140 RLQDVYMLNVKGLARGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKPSCGSRSLQVAYDTGDY 204

  Fly   192 -----WLIEANDRLTGGEKEEQLKPQILALLVQAKKE--LEDFRGLNDTYQEL------IGIQSA 243
                 ||.||                 ::|..:|..|  .||...|.|....|      :|..|.
Mouse   205 YHAIPWLEEA-----------------VSLFRRAHGEWKTEDEASLEDALDYLAFACFQVGNVSC 252

  Fly   244 SEEHAKNYETF--------LNALSEKALLNES-----------KPILEHAPIPEEGEPVGEFQAY 289
            :...::.:..:        .|.|..:.||.|:           :|.:.|....:..|.:.:....
Mouse   253 ALSLSREFLVYSPDNKRMARNVLKYERLLAENGHQMAAETAIQRPNVPHLQTRDTYEGLCQTLGS 317

  Fly   290 SLTCSGHWRLTPKEQRHLRCGYVTETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLT 354
            ..|   |:::.     .|.|.|.|.:.|:|.:.|.:.|.:...||:.||||.:...|...||:|.
Mouse   318 QPT---HYQIP-----SLYCSYETNSSPYLLLQPARKEVVHLRPLIALYHDFVSDEEAQKIRELA 374

  Fly   355 ENRLMRATITSHNESVVSNVRTSQFTFIPVTAHKVLSTIDQRVADMTNLNMK--YAEDHQFANYG 417
            |..|.|:.:.|..:.:....|.|:..::..|...:|.|:|.|:|.:|.|:::  |||..|..|||
Mouse   375 EPWLQRSVVASGEKQLQVEYRISKSAWLKDTVDPMLVTLDHRIAALTGLDIQPPYAEYLQVVNYG 439

  Fly   418 IGGHYGQHMDWFYQTTFDAGLVSSP----EMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKY 478
            |||||..|.|       .|...|||    :.|||:||.:.|||.|..||.|||......:...|.
Mouse   440 IGGHYEPHFD-------HATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYGNFSVPVVKN 497

  Fly   479 AAAFWHNLHASGVGDVRTQHGACPIIAGSKWVQNRWIRENDQSDRRPC 526
            ||.||.|||.||.||..|.|..||::.|.|||.|:||.|..|..||||
Mouse   498 AALFWWNLHRSGEGDGDTLHAGCPVLVGDKWVANKWIHEYGQEFRRPC 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	37/144 (26%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	72/176 (41%)
P4ha3	XP_006508007.1	P4Ha_N	31..157	CDD:369820	37/144 (26%)
P4ha3	XP_006508007.1	P4Hc	363..535	CDD:214780	72/178 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740