DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9698 and P4ha1

DIOPT Version :9

Sequence 1:	NP_651806.2	Gene:	CG9698 / 43629	FlyBaseID:	FBgn0039784	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_001303300.1	Gene:	P4ha1 / 18451	MGIID:	97463	Length:	534	Species:	Mus musculus

Alignment Length:	558	Identity:	173/558 - (31%)
Similarity:	281/558 - (50%)	Gaps:	58/558 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIFPVFSVLFLLFHQAIP-SVSGVEFFSSIHEMTKVFGYEQKMVLHMQKFLSDNQDKLDFLKARL 64
            ||:.|..:..||     | |::...||:||.:||.:...|:.:|..::.::...:|||:.:|...
Mouse     1 MIWVVLMMAILL-----PQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWA 60

  Fly    65 REFENERNEAREWGPSYFESPINKYLLNKRLTVDWQRVENLMATSTGEKPLTRLRKFRNRETMPD 129
            .:.:...:.|.:....:...|:|.:.|.|||..:|..:|||:.....:..::.|.  ..|:..|:
Mouse    61 EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLT--IQRQYFPN 123

  Fly   130 KKELEGAIDGLLRLQYVYRLKAKDLARGILDGVDYGTQLNSEHCVDIARLALRDQHPRLAHSWLI 194
            .::..||...|.|||..|.|....:::|.|.||.:.:.|.:|.|.::.::|..:........|:.
Mouse   124 DEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYYHTELWME 188

  Fly   195 EANDRLTGGEKEEQLKPQIL---------------ALLVQAKKELEDFRGLNDTYQELIG----- 239
            :|..:|..||.....|..:|               |||: .||.||    |:..:|...|
Mouse   189 QALTQLEEGELSTVDKVSVLDYLSYAVYQQGDLDKALLL-TKKLLE----LDPEHQRANGNLVYF 248

  Fly   240 --IQSASEEHAKNYETFLNALSEKALLNESKPI-LEHAPIPEEGEPVGEFQAYSLTCSGHW-RLT 300
              |.|..::..|:..   ...|::....:.|.| :::.|         |.|.|.:.|.|.. ::|
Mouse   249 EYIMSKEKDANKSAS---GDQSDQKTAPKKKGIAVDYLP---------ERQKYEMLCRGEGIKMT 301

  Fly   301 PKEQRHLRCGYVT-ETHPFLWIAPLKAEELFQDPLLVLYHDVIYQSEIDVIRKLTENRLMRATIT 364
            |:.|:.|.|.|.. ..:|...:||.|.|:.:..|.::.:||:|..:||::::.|.:.||.|||:
Mouse   302 PRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATV- 365

  Fly   365 SHN----ESVVSNVRTSQFTFIPVTAHKVLSTIDQRVADMTNLNMKYAEDHQFANYGIGGHYGQH 425
             |:    :...:..|.|:..::......|:|.|:.|:.|:|.|::..||:.|.||||:||.|..|
Mouse   366 -HDPETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPH 429

  Fly   426 MDWFYQTTFDAGLVSSPEMGNRIATVLFYLSDVAQGGGTAFPQLRTLLKPKKYAAAFWHNLHASG 490
            .|:..:...||  ......||||||.|||:|||:.||.|.||::...:.|||..|.||:||.|||
Mouse   430 FDFARKDEPDA--FRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASG 492

  Fly   491 VGDVRTQHGACPIIAGSKWVQNRWIRENDQSDRRPCEL 528
            .||..|:|.|||::.|:|||.|:|:.|..|..||||.|
Mouse   493 EGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9698	NP_651806.2	P4Ha_N	28..159	CDD:285528	33/130 (25%)
CG9698	NP_651806.2	P4Hc	345..516	CDD:214780	73/174 (42%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	33/130 (25%)
		TPR	205..238		9/37 (24%)
		P4Hc	345..518	CDD:214780	73/176 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100878
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820