DRSC/TRiP Functional Genomics Resources

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Protein Alignment PH4alphaNE2 and P4HA2

DIOPT Version :9

Sequence 1:NP_733378.1 Gene:PH4alphaNE2 / 43628 FlyBaseID:FBgn0039783 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_001136071.1 Gene:P4HA2 / 8974 HGNCID:8547 Length:535 Species:Homo sapiens


Alignment Length:571 Identity:170/571 - (29%)
Similarity:258/571 - (45%) Gaps:74/571 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MLFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTI 65
            |..|...|| |.:    ||.|  :..|..|..|:.:|.|::..|.:||.::::.......|...|
Human     1 MKLWVSALL-MAW----FGVL--SCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKI 58

  Fly    66 KWGVFKMMKRRQEYKSSME-IFANPIDTFSLIRHMQSNW--LMWLLYLETPVG-------QEELF 120
            |....||.....:..:..| ..|:|::.:.|::.:.::|  |..|:..::..|       |.:.|
Human    59 KSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFF 123

  Fly   121 FVDSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNN 185
            ..|.         |.|.||:.:.::|.||::....|::|.|.|.:|.:.|...||..:|....|.
Human   124 PTDE---------DEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNE 179

  Fly   186 SRWYAAEQW-------ISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAY 243
            ..:|....|       :.|..||...||...|.......:|.||.|              ||:..
Human   180 GDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHR--------------ALELT 230

  Fly   244 QVALKLSPHDPEI-----YEEYRILEKRDLTLSD------IEP---IEQDKDNSHERLVLPPCCS 294
            :..|.|.|.....     |.|..:.|:|:.||::      ..|   .|:..|...||.|....|.
Human   231 RRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCR 295

  Fly   295 GR--CQVPRNLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEH 356
            |.  ...||....|:|.|:|.. :|.|.:||.|.|.....|.:|..:|::|.:|...|:..:|..
Human   296 GEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPK 360

  Fly   357 MLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGL 421
            :..:...||...  ...|.:||.|||.|...|.:....::..|:...|||.:.:.|..||.|||:
Human   361 LARATVRDPKTG--VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGV 423

  Fly   422 GGFFETHLDMLLS-EKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYN 483
            ||.:|.|.|...: |::.|.  ||.:|:||.|.|:::|..||.|.||.|...::|:.|:|:||||
Human   424 GGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYN 488

  Fly   484 LDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEV 534
            |...|.....:.|..|||:||.|||.:||.::.||||.|||     .|.||
Human   489 LLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC-----GSTEV 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PH4alphaNE2NP_733378.1 P4Ha_N 33..161 CDD:285528 31/137 (23%)
TPR repeat 175..200 CDD:276809 6/31 (19%)
TPR_16 176..254 CDD:290168 19/84 (23%)
TPR repeat 219..249 CDD:276809 7/29 (24%)
TPR_2 220..253 CDD:285020 8/32 (25%)
P4Hc 342..513 CDD:214780 64/173 (37%)
P4HA2NP_001136071.1 P4Ha_N 26..155 CDD:311993 31/137 (23%)
TPR 207..240 11/46 (24%)
P4Hc 346..519 CDD:214780 65/174 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D192165at33208
OrthoFinder 1 1.000 - - FOG0000199
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X129
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

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