DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE2 and p4htmb

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_001340234.2	Gene:	p4htmb / 799930	ZFINID:	ZDB-GENE-110131-7	Length:	510	Species:	Danio rerio

Alignment Length:	433	Identity:	98/433 - (22%)
Similarity:	163/433 - (37%)	Gaps:	129/433 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 LAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRG---PKLADLCRI----LGQVQ--- 230
            |.:.:|..|.|...:|.:..::|..:..:.:..:|.:....   |:...|.||    :|.||
Zfish    75 LLLYVHYNNGSNAISANRDFTSSDSSSHKVTGASDAQATADSGFPRNMFLPRIEGIRVGHVQKVS 139

  Fly   231 -MKQRNHEGALQAYQVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCS 294
             :..:.||         :|.....|.::|....|.:.:..:  :..:.|.|.....::::|   .
Zfish   140 LVSGKVHE---------MKTLSLKPLLFEIPDFLSEEECAV--VVRLAQLKGLMESQVMVP---E 190

  Fly   295 GRCQVPRNLSNLYCVYNHVTSP-----FLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSK 354
            |:.::.:.| ||        ||     ||.|    .:...:.|..:|.|..:  ::...:.:.:.
Zfish   191 GQEELDQQL-NL--------SPEEIFNFLDL----NQDGQLQPHEILTHSRV--RDGIWLTSENL 240

  Fly   355 EHMLPSATTDPDA-------------SD-----------DETQVDTYRTSKSVW-YSSD-----F 389
            :.:......|.|.             ||           :.:|:  .|.|:..| |...     .
Zfish   241 KEIYDGLKADLDGNGLLSLEEFGRLRSDAFQRFLLQRGVERSQL--VRNSRHTWLYQGQGAHQVL 303

  Fly   390 NDTTKKIT--ERLGDATGLDMNSTEFYQVINYGLGGFFETHLD--------------MLLSEKNR 438
            .|..|::|  .||..:.   :..:|..||:.|..||.:..|.|              :..:..:.
Zfish   304 QDLRKRVTLLTRLPSSL---VELSEPLQVVRYEQGGHYHAHHDSGPVYPETACTHTRLAANTTSP 365

  Fly   439 FNGTSDRIATTLFYLNEVRQGGGTYFP---------------------------RLNLTVFPQPG 476
            |. ||.|..|.|||||.|::||.|.||                           :.||.|.|..|
Zfish   366 FQ-TSCRYITVLFYLNNVQEGGETTFPVADNRTYEEASLIQNDVDLLDTRKHCDKGNLRVKPVKG 429

  Fly   477 SALFWYNLDTKGNDHMG-----SLHTGCPVIVGSKWVMSKWIN 514
            :|:||||..:.|...:|     |||.||.|..|:|||.:.|||
Zfish   430 TAVFWYNYLSDGRGWVGEQDEYSLHGGCVVTQGTKWVANNWIN 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528
		TPR repeat	175..200	CDD:276809	6/23 (26%)
		TPR_16	176..254	CDD:290168	17/88 (19%)
		TPR repeat	219..249	CDD:276809	8/37 (22%)
		TPR_2	220..253	CDD:285020	9/40 (23%)
		P4Hc	342..513	CDD:214780	60/248 (24%)
p4htmb	XP_001340234.2	EF-hand_7	204..262	CDD:290234	8/63 (13%)
		EFh	204..262	CDD:298682	8/63 (13%)
		P4Hc	285..471	CDD:214780	55/189 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583462
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740