DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE2 and P4htm

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_083220.3	Gene:	P4htm / 74443	MGIID:	1921693	Length:	503	Species:	Mus musculus

Alignment Length:	446	Identity:	103/446 - (23%)
Similarity:	146/446 - (32%)	Gaps:	166/446 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 SLKPI-----------DCLAIGLHLMNNSRWYAAEQWISAS----IEAYDQKSSQTDMELLRGPK 218
            ||||:           :|..| :||       |..:.:..|    .|.|::..|...:..|
Mouse   140 SLKPLLFEIPGFLSDEECRLI-IHL-------AQMKGLQRSQILPTEEYEEAMSAMQVSQL---- 192

  Fly   219 LADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNS 283
              ||.::|.|      ||:|.||..:|.                                    :
Mouse   193 --DLFQLLDQ------NHDGRLQLREVL------------------------------------A 213

  Fly   284 HERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTL 348
            ..||     .:||...|.|:..:|..        ::..|....:||:..|        |..:...
Mouse   214 QTRL-----GNGRWMTPENIQEMYSA--------IKADPDGDGVLSLQEF--------SNMDLRD 257

  Fly   349 IRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVW--YSSDFNDTTKKITERLGDATGLDMNST 411
            .....:.|...|.             :..|.|...|  .....:...:.|.:|:...|.|.....
Mouse   258 FHKYMRSHKAESN-------------ELVRNSHHTWLHQGEGAHHVMRAIRQRVLRLTRLSPEIV 309

  Fly   412 EF---YQVINYGLGGFFETHLD--------------MLLSEKNRFNGTSDRIATTLFYLNEVRQG 459
            ||   .||:.||.||.:..|:|              ::.:|...|. ||.|..|.|||||.|..|
Mouse   310 EFSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFE-TSCRYMTVLFYLNNVTGG 373

  Fly   460 GGTYFP---------------------------RLNLTVFPQPGSALFWYNLDTKGNDHMG---- 493
            |.|.||                           :.||.|.||.|:|:||||....|...:|
Mouse   374 GETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGEVDD 438

  Fly   494 -SLHTGCPVIVGSKWVMSKWIND---------MGQEFTRPCVESSLSSNEVLSAER 539
             |||.||.|..|:||:.:.|||.         ..||..|...|..:.|....:.:|
Mouse   439 YSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGMDSQPEWALDR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528
		TPR repeat	175..200	CDD:276809	6/28 (21%)
		TPR_16	176..254	CDD:290168	19/81 (23%)
		TPR repeat	219..249	CDD:276809	10/29 (34%)
		TPR_2	220..253	CDD:285020	10/32 (31%)
		P4Hc	342..513	CDD:214780	59/221 (27%)
P4htm	NP_083220.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..110
		EF-hand_7	193..253	CDD:290234	22/122 (18%)
		EFh	195..253	CDD:298682	20/120 (17%)
		P4Hc	247..459	CDD:214780	60/233 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740