Protein Alignment PH4alphaNE2 and P4ha1

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_742059.2
• Gene: P4ha1 / 64475
• RGDID: 621000
• Length: 534
• Species: Rattus norvegicus
• Alignment Length: 559
• Identity: 165/559 - (29%)
• Similarity: 267/559 - (47%)
• Gaps: 57/559 - (10%)

  Fly     2 LFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66
            :.|.::::|:|        |.:.:|...|..|:..|.|:::.|.|||::::...:|...|.:.||
  Rat     1 MIWGVLMMGIL--------LPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIK 57

  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNW--LMWLLYLETPVGQEELFFVDSRMPL 128
            ....|:.:.........|.| .:|::.|.|::.:.:.|  |..|:..:...|     |: |.:.:
  Rat    58 KWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDG-----FI-SNLTI 116

  Fly   129 LPKYF----DFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWY 189
            ..:||    |.:.||:.:.::|.||.:.::.|:||.|.||::.|.|...||..:|......:.:|
  Rat   117 QRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYY 181

  Fly   190 AAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDP 254
            ..|.|:..::...::....|          .|...:|..:...........:|..:..||...||
  Rat   182 HTELWMEQALMQLEEGEMST----------VDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDP 236

  Fly   255 E--------IYEEYRILEKRDLT------LSDIEPIEQDK----DNSHERLVLPPCCSGR--CQV 299
            |        :|.||.:.:::|..      .||.:...:.|    |...||......|.|.  ...
  Rat   237 EHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMT 301

  Fly   300 PRNLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATT 363
            ||....|:|.|:... :|...|||.|.|.....|.::..||:||..|..:::..:|..:..:...
  Rat   302 PRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVH 366

  Fly   364 DPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETH 428
            ||:.....|.  .||.|||.|.|...:....:|..|:.|.||||:::.|..||.|||:||.:|.|
  Rat   367 DPETGKLTTA--QYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPH 429

  Fly   429 LDML-LSEKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGND 490
            .|.. ..|.:.|.  ||.:||||.|||:::|..||.|.||.:..:|:|:.|:|:|||||...|..
  Rat   430 FDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEG 494

  Fly   491 HMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSL 529
            ...:.|..|||:||:|||.:||:::.||||.|||..|.|
  Rat   495 DYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSEL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	35/136 (26%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:433202	10/77 (13%)
		NrfG	217..>260	CDD:443378	9/50 (18%)
		TPR repeat	219..249	CDD:276809	3/29 (10%)
		P4Hc	342..513	CDD:214780	68/173 (39%)
P4ha1	NP_742059.2	P4Ha_N	24..155	CDD:462433	35/136 (26%)
		TPR	205..238		6/32 (19%)
		P4Hc	345..518	CDD:214780	69/174 (40%)