DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE2 and Y43F8B.19

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001123044.2	Gene:	Y43F8B.19 / 6418801	WormBaseID:	WBGene00077688	Length:	243	Species:	Caenorhabditis elegans

Alignment Length:	241	Identity:	71/241 - (29%)
Similarity:	107/241 - (44%)	Gaps:	47/241 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 IKTEILSIDPFVVLLHDMISQKESTLIRTSSK--EHML--PSATTDPDASD--------DETQV- 374
            :|.|:::..|.:|:..|:.:.|:   :|...:  ||:.  .....:.|.:|        :.|||
Worm    22 VKVEVVAWRPGLVIYRDLFTGKQ---VRDHLELMEHLKFEEQLVVNDDGNDIVSKIRRANGTQVF 83

  Fly   375 -DTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLL--SEK 436
             :.:..::|:|      ||.|.:...|...|..|:      ..::|..||.:..|.|.||  |||
Worm    84 HEDHPAARSIW------DTAKNLLPNLNFKTAEDI------LALSYNPGGHYAAHHDYLLYPSEK 136

  Fly   437 N-----RFNGTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSL- 495
            .     |.||  :|..|.:........||.|.||||...|..:||.|.||:|  ..||.....|
Worm   137 EWDEWMRVNG--NRFGTLIMAFGAAESGGATVFPRLGAAVRTKPGDAFFWFN--AMGNSEQEDLS 197

  Fly   496 -HTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEVLSAERL 540
             |.|||:..|.|.:.:.|:....|    |.:|.:|||:. |||..|
Worm   198 EHAGCPIYKGQKQISTIWLRMRDQ----PILEQTLSSDS-LSASLL 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528
		TPR repeat	175..200	CDD:276809
		TPR_16	176..254	CDD:290168
		TPR repeat	219..249	CDD:276809
		TPR_2	220..253	CDD:285020
		P4Hc	342..513	CDD:214780	55/193 (28%)
Y43F8B.19	NP_001123044.2	P4Hc	43..217	CDD:214780	56/192 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810