DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and p4ha3

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	555	Identity:	158/555 - (28%)
Similarity:	250/555 - (45%)	Gaps:	87/555 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66
            ||..|.||.|  ...|||::         ..|:::::..::.|..|:.::....|..|::.:.||
Zfish     7 LFIVLYLLNM--PDESFGEM---------FTSMLSVNQAVSAERKLIDHLIIYIEHEAQRLEDIK 60

  Fly    67 WGVFKMMKRRQE--YKSSMEIFANPIDTFSLIRHMQSNWLMWLLYLET----PVGQEELFFVDSR 125
             ..|..:....:  |....:..||||..|.|::.::|.||..:...|.    .|.:|:...::|.
Zfish    61 -RFFSRVTSLHDGIYNEPSDPIANPIAAFKLVKRLKSEWLNVVHSTEAEENIKVLREDYRRMESS 124

  Fly   126 MPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKG----LLDGVQY-----NSSLKPIDCLAIGLH 181
               |||..|...||.|:.::|..|.:....:.:|    :.|.|.:     :..|...||..:|..
Zfish   125 ---LPKLEDLRGAAHGLMRLQDVYNLHVESLVRGHFQQISDPVDFYKLSVSDMLSGDDCFLVGKV 186

  Fly   182 LMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRGPK--------LADLCRILGQVQMKQRNHEG 238
            ..:...:|.:..|...::            .|.||.:        |.|....|.....|..|...
Zfish   187 AYDLEDYYHSVLWFEEAV------------RLFRGTEWSPENEGTLEDALDHLAFSHFKTGNISH 239

  Fly   239 ALQAYQVALKLSPHDP---------EIYEEYRILEKR------DLTLSDIEPIEQDKDNSHERLV 288
            ||   .::.:|..|||         |.||  ::|.:.      .|||...:.|.....|::|:|
Zfish   240 AL---SLSRELLLHDPMNRRVHFNVEKYE--KLLNENLPATSSGLTLKRPDGIYLRTRNAYEQL- 298

  Fly   289 LPPCCSGRCQVPRNLSN--LYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRT 351
                |..:...|::..|  |:|.|....||.|.|.||:.||:|:.|:|||.|..::|.|:..||
Zfish   299 ----CQTKGSQPKHFENPSLFCDYFTNGSPALFLQPIRREIISLQPYVVLFHGFVTQAEAKNIR- 358

  Fly   352 SSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNS--TEFY 414
               ::.:|.......||........||.|||.|.....::...|:.:|:...|||::..  .|:.
Zfish   359 ---KYAMPGLRRSVVASGMNQATAEYRISKSAWLKESAHEVVGKLDQRITLVTGLNVQPPYAEYL 420

  Fly   415 QVINYGLGGFFETHLDMLLSEKN---RFNGTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPG 476
            ||:|||:||.:|.|.|...|:.:   |.. |.:|:||.:.||:.|:.||.|.|...|.:|.....
Zfish   421 QVVNYGIGGHYEPHFDHATSDSSPLYRLK-TGNRVATIMIYLSPVQAGGSTAFIYANFSVPVVQN 484

  Fly   477 SALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSK 511
            :||||:||...|..::.:||.|||||||:||.|.|
Zfish   485 AALFWWNLHKNGQGNVDTLHAGCPVIVGNKWGMFK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	32/137 (23%)
		TPR repeat	175..200	CDD:276809	4/24 (17%)
		TPR_16	176..254	CDD:290168	15/85 (18%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		TPR_2	220..253	CDD:285020	7/32 (22%)
		P4Hc	342..513	CDD:214780	64/175 (37%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	32/133 (24%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	63/173 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950