Protein Alignment PH4alphaNE2 and P4HTM

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_808807.2
• Gene: P4HTM / 54681
• HGNCID: 28858
• Length: 563
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 87/413 - (21%)
• Similarity: 131/413 - (31%)
• Gaps: 169/413 - (40%)

  Fly   223 CR-ILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEE-YRILEKRDLTLSDIEPIEQDKDNS-- 283
            || |:...|||      .||..|:.      ..|.||| ...::...|.|..:  ::|::|..
Human   156 CRLIIHLAQMK------GLQRSQIL------PTEEYEEAMSTMQVSQLDLFRL--LDQNRDGHLQ 206

  Fly   284 -HERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKTE-----ILSIDPFVVLLHDMIS 342
             .|.|......:|....|.::..:|             |.||.:     :||:..|        |
Human   207 LREVLAQTRLGNGWWMTPESIQEMY-------------AAIKADPDGDGVLSLQEF--------S 250

  Fly   343 QKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVW-YSSD-FNDTTKKITERLGDATG 405
            ..:........:.|...|:             :..|.|...| |..: .:...:.|.:|:...|.
Human   251 NMDLRDFHKYMRSHKAESS-------------ELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTR 302

  Fly   406 LD---MNSTEFYQVINYGLGGFFETHLD--------------MLLSEKNRFNGTSDRIA------ 447
            |.   :..:|..||:.||.||.:..|:|              ::.:|...|..:..:::
Human   303 LSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGLP 367

  Fly   448 ------------------------------------------------------TTLFYLNEVRQ 458
                                                                  |.|||||.|..
Human   368 SILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTG 432

  Fly   459 GGGTYFP---------------------------RLNLTVFPQPGSALFWYNLDTKGNDHMG--- 493
            ||.|.||                           :.||.|.||.|:|:||||....|...:|
Human   433 GGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVD 497

  Fly   494 --SLHTGCPVIVGSKWVMSKWIN 514
              |||.||.|..|:||:.:.|||
Human   498 DYSLHGGCLVTRGTKWIANNWIN 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433
		TPR repeat	175..200	CDD:276809
		TPR_16	176..254	CDD:433202	9/31 (29%)
		NrfG	217..>260	CDD:443378	13/38 (34%)
		TPR repeat	219..249	CDD:276809	9/26 (35%)
		P4Hc	342..513	CDD:214780	56/281 (20%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:463900	15/82 (18%)
		P4Hc	246..519	CDD:214780	57/293 (19%)