Protein Alignment PH4alphaNE2 and P4HA1

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 165/557 - (29%)
• Similarity: 265/557 - (47%)
• Gaps: 53/557 - (9%)

  Fly     2 LFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66
            :.|.::::|:|        |.::.|...|..|:..|.|:::.|.|||::::...:|...|.:.||
Human     1 MIWYILIIGIL--------LPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIK 57

  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLP 130
            ....|:.:.........|.| .:|::.|.|::.:.:.|    ..||..|.::......|.:.:..
Human    58 KWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEW----SELENLVLKDMSDGFISNLTIQR 118

  Fly   131 KYF----DFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAA 191
            :||    |.:.||:.:.::|.||.:.:..|:||.|.||::.|.|...||..:|......:.:|..
Human   119 QYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHT 183

  Fly   192 EQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQ---MKQRNHEGALQAYQVALKLSPHD 253
            |.|:..::...|:....|          .|...:|..:.   .:|.:.:.||...:..|:|.|..
Human   184 ELWMEQALRQLDEGEIST----------IDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEH 238

  Fly   254 PEI-----YEEYRILEKRDLTLSDIEPIEQDK----------DNSHERLVLPPCCSGR--CQVPR 301
            ...     |.||.:.:::|:..|..:.....|          |...||......|.|.  ...||
Human   239 QRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPR 303

  Fly   302 NLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDP 365
            ....|:|.|:... :|...|||.|.|.....|.::..||:||..|..:::..:|..:..:...||
Human   304 RQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDP 368

  Fly   366 DASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLD 430
            :.....|.  .||.|||.|.|...|....:|..|:.|.||||:::.|..||.|||:||.:|.|.|
Human   369 ETGKLTTA--QYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFD 431

  Fly   431 ML-LSEKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHM 492
            .. ..|.:.|.  ||.:||||.|||:::|..||.|.||.:..:|:|:.|:|:|||||...|....
Human   432 FARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDY 496

  Fly   493 GSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSL 529
            .:.|..|||:||:|||.:||:::.||||.|||..|.|
Human   497 STRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSEL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	34/134 (25%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:433202	14/80 (18%)
		NrfG	217..>260	CDD:443378	9/50 (18%)
		TPR repeat	219..249	CDD:276809	6/32 (19%)
		P4Hc	342..513	CDD:214780	69/173 (40%)
P4HA1	NP_000908.2	P4Ha_N	24..155	CDD:462433	34/134 (25%)
		TPR	205..238		7/32 (22%)
		P4Hc	345..518	CDD:214780	70/174 (40%)