DRSC/TRiP Functional Genomics Resources

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Protein Alignment PH4alphaNE2 and P4HA1

DIOPT Version :9

Sequence 1:NP_733378.1 Gene:PH4alphaNE2 / 43628 FlyBaseID:FBgn0039783 Length:542 Species:Drosophila melanogaster
Sequence 2:NP_000908.2 Gene:P4HA1 / 5033 HGNCID:8546 Length:534 Species:Homo sapiens


Alignment Length:557 Identity:165/557 - (29%)
Similarity:265/557 - (47%) Gaps:53/557 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66
            :.|.::::|:|        |.::.|...|..|:..|.|:::.|.|||::::...:|...|.:.||
Human     1 MIWYILIIGIL--------LPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIK 57

  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLP 130
            ....|:.:.........|.| .:|::.|.|::.:.:.|    ..||..|.::......|.:.:..
Human    58 KWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEW----SELENLVLKDMSDGFISNLTIQR 118

  Fly   131 KYF----DFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAA 191
            :||    |.:.||:.:.::|.||.:.:..|:||.|.||::.|.|...||..:|......:.:|..
Human   119 QYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHT 183

  Fly   192 EQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQ---MKQRNHEGALQAYQVALKLSPHD 253
            |.|:..::...|:....|          .|...:|..:.   .:|.:.:.||...:..|:|.|..
Human   184 ELWMEQALRQLDEGEIST----------IDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEH 238

  Fly   254 PEI-----YEEYRILEKRDLTLSDIEPIEQDK----------DNSHERLVLPPCCSGR--CQVPR 301
            ...     |.||.:.:::|:..|..:.....|          |...||......|.|.  ...||
Human   239 QRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPR 303

  Fly   302 NLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDP 365
            ....|:|.|:... :|...|||.|.|.....|.::..||:||..|..:::..:|..:..:...||
Human   304 RQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDP 368

  Fly   366 DASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLD 430
            :.....|.  .||.|||.|.|...|....:|..|:.|.||||:::.|..||.|||:||.:|.|.|
Human   369 ETGKLTTA--QYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFD 431

  Fly   431 ML-LSEKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHM 492
            .. ..|.:.|.  ||.:||||.|||:::|..||.|.||.:..:|:|:.|:|:|||||...|....
Human   432 FARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDY 496

  Fly   493 GSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSL 529
            .:.|..|||:||:|||.:||:::.||||.|||..|.|
Human   497 STRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSEL 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PH4alphaNE2NP_733378.1 P4Ha_N 33..161 CDD:285528 33/132 (25%)
TPR repeat 175..200 CDD:276809 5/24 (21%)
TPR_16 176..254 CDD:290168 14/80 (18%)
TPR repeat 219..249 CDD:276809 6/32 (19%)
TPR_2 220..253 CDD:285020 8/35 (23%)
P4Hc 342..513 CDD:214780 69/173 (40%)
P4HA1NP_000908.2 P4Ha_N 25..112 CDD:400573 20/90 (22%)
TPR 205..238 7/32 (22%)
P4Hc 345..518 CDD:214780 70/174 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1591
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D192165at33208
OrthoFinder 1 1.000 - - FOG0000199
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X129
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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