DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE2 and p4ha2

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	526	Identity:	149/526 - (28%)
Similarity:	241/526 - (45%)	Gaps:	54/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SVVNMDDMLNLEDDLVSNV-EKLAEALARKAKTIKWG--VFKMMKRRQEYKSSME---IFANPID 91
            |...|.|::..|.||:.:: |.:.|...|.:|..:|.  |.::..|     |:.:   ...:|::
Frog    26 STGQMTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSR-----STADPEGYLGHPVN 85

  Fly    92 TFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYF----DFIDAAEGIRKMQATYQMF 152
            .:.|::...::|..    ||..|.|:......:......:||    |...||..:.::|.||::.
Frog    86 AYKLVKRFNTDWSS----LENLVLQDSAKGFIANFTFQREYFPTEEDETGAARALMRIQDTYKLD 146

  Fly   153 SSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRGP 217
            ...||||.|.|..|.|||...|...:|....::..:|....|:..:::..|:.......::
Frog   147 PDVIAKGKLPGTNYISSLSADDSFGMGKIAYHDGDYYHTVLWMQQALKQMDEGEDAVVNKV---- 207

  Fly   218 KLADLCRILGQVQMKQRNHEGALQAYQVALKLSP-HDPEI-----YEEYRILEKRDLTLSDIEPI 276
               |:...|.....:..:...||:..:..|.|.| ||..:     :|:.:..:|.:|..::....
Frog   208 ---DVLDYLSYTVFQLGDVPRALELTKRLLALDPNHDRAVNNLKYFEKMQEKQKAELKQNESTNT 269

  Fly   277 E----------QDKDNSHERLVLPPCCSGR--CQVPRNLSNLYCVY-NHVTSPFLQLAPIKTEIL 328
            |          :..|...||.|....|.|.  ...||....|:|.| |...||:|.|:|:|.|..
Frog   270 ESATRQPGVYSRPLDYLPERDVYEALCRGEGVKMNPRRQRRLFCRYHNGNRSPYLILSPVKVEDE 334

  Fly   329 SIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTT 393
            ...|.:|...:.:|.:|...|:..:|..:..:...||...  ...|..||.|||.|...:.:...
Frog   335 WDSPRIVRYLNALSDEEIAKIKELAKPKLARATVRDPKTG--VLSVANYRVSKSAWLEENDDPVI 397

  Fly   394 KKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFN-----GTSDRIATTLFYL 453
            .::..|:...|||.:::.|..||.|||:||.:|.|.|  .|.|:..:     ||.:|:||.|.|:
Frog   398 ARVNLRMQAITGLTVDTAELLQVANYGMGGQYEPHFD--FSRKDEPDVFKRLGTGNRVATFLNYM 460

  Fly   454 NEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQ 518
            ::|..||.|.||.....::|:.|:|:|||||...|.....:.|..|||:||||||.:||.::.||
Frog   461 SDVEAGGATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWFHERGQ 525

  Fly   519 EFTRPC 524
            ||.|||
Frog   526 EFLRPC 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	33/137 (24%)
		TPR repeat	175..200	CDD:276809	3/24 (13%)
		TPR_16	176..254	CDD:290168	12/78 (15%)
		TPR repeat	219..249	CDD:276809	5/29 (17%)
		TPR_2	220..253	CDD:285020	7/33 (21%)
		P4Hc	342..513	CDD:214780	63/175 (36%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	20/94 (21%)
		TPR repeat	166..201	CDD:276809	5/34 (15%)
		TPR repeat	206..236	CDD:276809	5/36 (14%)
		P4Hc	348..521	CDD:214780	64/176 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010