Protein Alignment PH4alphaNE2 and LOC4577387

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: XP_001237637.4
• Gene: LOC4577387 / 4577387
• VectorBaseID: AGAMI1_013198
• Length: 514
• Species: Anopheles gambiae
• Alignment Length: 524
• Identity: 164/524 - (31%)
• Similarity: 250/524 - (47%)
• Gaps: 61/524 - (11%)

  Fly    25 NAQQRFARSVVNMDDMLNLEDDLVSNV-------EKLAEALARKAKTIKWGVFKMMKRRQEYKSS 82
            |....:..||..|..:|.||:.||:::       |:..|.|.|:...::..:.|.:|...||.|
Mosquito    22 NVHGEYYSSVEQMRKLLKLEESLVASLGQYIKLHEQKIEFLHRQRDLLEKELKKGLKDDIEYSS- 85

  Fly    83 MEIFANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQA 147
                 ||:..|.::..:.::|.....:::..||.:.     .....:|.:.|.|...||:.::|.
Mosquito    86 -----NPVSAFLMVNRLVNDWERLRAFMDMDVGAKL-----QNTTEMPTHEDLIGVVEGLARLQD 140

  Fly   148 TYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDME 212
            .|::.:.::|.|.|........||..:|..||..|.....:..|..|:..|:..:...|.
Mosquito   141 MYELNAKEMASGKLLDRTIGRQLKTAECYEIGNKLTAAKSYRHAVSWLRESLRLWTMDSP----- 200

  Fly   213 LLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIE 277
               |....::...|......|..:|.||:..|..|||.|      :..|.|..:       ||:|
Mosquito   201 ---GVSKVEVMNALSYALSHQGEYEEALELTQKVLKLQP------DNQRALNSK-------EPLE 249

  Fly   278 QDKDNSHERLVLPP-----------CCSGRCQVP-RNLSNLYCVYNHVTSPFLQLAPIKTEILSI 330
            :..:...:..:.||           .|.|..|.| :.|:.|.|.|.|..:|||:::|:|.:.::.
Mosquito   250 KWIEYKKQHGLPPPVPEPYVKNYPSLCRGDDQRPAKELAKLRCRYEHNRTPFLRISPLKLQEVNH 314

  Fly   331 DPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKK 395
            ||.:|:.||:||.||...|.:.||..|..|...|    |.|..|...|||.:.|.....:...:.
Mosquito   315 DPMIVMYHDVISNKEIDAIISISKPLMHRSMVGD----DHEKAVSKTRTSSNAWLDDVMHPVVRT 375

  Fly   396 ITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNR----FNGTSDRIATTLFYLNEV 456
            :::|..|.|.|.|.:.|..||.|||:||.:..|.|..::|:.:    ..|..:||||.::||::|
Mosquito   376 LSQRTEDMTNLAMTAAERLQVGNYGIGGHYLPHYDYAVAEEGKEVYPSIGKGNRIATVMYYLSDV 440

  Fly   457 RQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGN-DHMGSLHTGCPVIVGSKWVMSKWINDMGQEF 520
            ..||.|.||:|.|.||||.|||:|||||...|. ||. :||..|||.||||||.:|||::.||||
Mosquito   441 AIGGATVFPQLGLGVFPQKGSAIFWYNLHANGTVDHR-TLHGACPVFVGSKWVGNKWIHERGQEF 504

  Fly   521 TRPC 524
            .|.|
Mosquito   505 RRSC 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	33/136 (24%)
		TPR repeat	175..200	CDD:276809	7/24 (29%)
		TPR_16	176..254	CDD:433202	18/77 (23%)
		NrfG	217..>260	CDD:443378	10/42 (24%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		P4Hc	342..513	CDD:214780	74/175 (42%)
LOC4577387	XP_001237637.4	None