DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PH4alphaNE2 and PH4alphaPV

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_733395.1	Gene:	PH4alphaPV / 43640	FlyBaseID:	FBgn0051015	Length:	525	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	183/545 - (33%)
Similarity:	288/545 - (52%)	Gaps:	44/545 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWG 68
            |.|.:..:|...:....||:...::....||..|..:|:||..|:.|:|..|..|.:|.:|::..
  Fly     6 WLLPVRVLLTYQVLLLLLRQAKGEESHCTSVAGMVKLLDLEAQLIDNLEDYAVELEKKLQTVRRS 70

  Fly    69 VFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKY 132
            :..:.....:.:||.|.: :||:::|||||.|..:|::|.||::.|||..::..:......:|.:
  Fly    71 ITSLRLENDKARSSTEEYLSNPLNSFSLIRRMNRDWIIWQLYMDDPVGISQVERIQELREHMPTH 135

  Fly   133 FDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISA 197
            .|..:|...:.::|:||.:...:|:.|.|:|.|||.||..:|..|:|..|.:...:.||..||..
  Fly   136 TDVEEAVTALDRIQSTYGLKVPEISHGFLNGKQYNVSLTVLDTYAMGQILFDQKNYLAAASWIYQ 200

  Fly   198 SIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRI 262
            |:...:..|....:|:.:.    ::..:..:..:|...|..||:...:||..:|||.::     :
  Fly   201 SVVLMEAFSMAAPLEISKN----EVRMVYAETLLKLNQHADALKVVNIALTDNPHDIKL-----L 256

  Fly   263 LEKRDLTLSDIEPIEQDKDNSHERLVLPPC--------------CSGRCQVPRNL-SNLYCVYNH 312
            |:|     |:||.:.:...|:     .||.              |.|  |.|.:. |.|||:||.
  Fly   257 LKK-----SEIETMIRTGTNN-----APPVKVQATGVPTAYQIGCRG--QFPPSADSKLYCLYNR 309

  Fly   313 VTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTY 377
            .|||||.|||:|.|::.:||::||.||::|.||...::..:...:  ...|...||....:|...
  Fly   310 TTSPFLILAPLKMELVGLDPYMVLYHDVLSPKEIKELQGMATPGL--KRATVYQASSGRNEVVKT 372

  Fly   378 RTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGT 442
            ||||..|:...:|..|.::..|:.|.||.::..:|..|::||||||.::.|.|..  .|...|.|
  Fly   373 RTSKVAWFPDGYNPLTVRLNARISDMTGFNLYGSEMLQLMNYGLGGHYDQHYDFF--NKTNSNMT 435

  Fly   443 S---DRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVG 504
            :   |||||.||||.:|.|||.|.||.:...||||.||.:.||||...|.....:||..||||||
  Fly   436 AMSGDRIATVLFYLTDVEQGGATVFPNIRKAVFPQRGSVVMWYNLKDNGQIDTQTLHAACPVIVG 500

  Fly   505 SKWVMSKWINDMGQEFTRPCVESSL 529
            ||||.:|||.:..|.|:|||::..:
  Fly   501 SKWVCNKWIREREQIFSRPCLKKRM 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	39/128 (30%)
		TPR repeat	175..200	CDD:276809	8/24 (33%)
		TPR_16	176..254	CDD:290168	18/77 (23%)
		TPR repeat	219..249	CDD:276809	6/29 (21%)
		TPR_2	220..253	CDD:285020	7/32 (22%)
		P4Hc	342..513	CDD:214780	71/173 (41%)
PH4alphaPV	NP_733395.1	P4Ha_N	35..164	CDD:285528	39/128 (30%)
		TPR_11	179..250	CDD:290150	16/74 (22%)
		TPR repeat	179..213	CDD:276809	9/33 (27%)
		TPR repeat	218..248	CDD:276809	6/33 (18%)
		P4Hc	339..510	CDD:214780	72/174 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461767
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910