Protein Alignment PH4alphaNE2 and PH4alphaNE1

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_733374.1
• Gene: PH4alphaNE1 / 43625
• FlyBaseID: FBgn0039780
• Length: 537
• Species: Drosophila melanogaster
• Alignment Length: 530
• Identity: 151/530 - (28%)
• Similarity: 259/530 - (48%)
• Gaps: 24/530 - (4%)

  Fly     6 LVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVF 70
            ::|:|:::| |:.|.|..:     :..|:..::|:|:.|..|...:.....|:....:.::..:.
  Fly     5 VLLVGLIFL-LAQGSLASD-----YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELS 63

  Fly    71 KMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLL--PKY 132
            .:.|......|..|.: .||::.:.|::.:.::|.  |:.....:..||:.|..:|...|  |..
  Fly    64 SIEKEHTMAASDTENYLTNPVNVYRLMKRLHTDWS--LMEGRVQLMAEEMNFNATREYGLSYPSQ 126

  Fly   133 FDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISA 197
            .|...||..:.::|:||::..:.:|:|:|:||:|.|.:...||..:|..|.....:...:.|:..
  Fly   127 EDVEGAALALVRLQSTYKLDVAQVAQGILNGVKYGSDMSWQDCFELGQQLFEMEDYNNTKVWLRE 191

  Fly   198 SIEAYDQKSSQTDMEL--LRGPKLADLCRILGQVQMKQRNHEGALQ-AYQVALKLSPHDPEIYEE 259
            |:|...:::|.....|  ..||....|.::  :...|.....|... |::::.::...||:....
  Fly   192 SMERLRRQTSHAPSHLAPTSGPDTVTLNKM--EATAKSLFQLGDFDTAFELSQRVLQFDPKRIRN 254

  Fly   260 YRILEKRDLTLSDIEPIEQDKDN-----SHERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQ 319
            :.:.:|......||:.:...|.:     |.|.......|.|... |.....|.|.|:....|:..
  Fly   255 WHLGDKGTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKVCRGEVH-PIVRQELRCRYSRGNHPYRF 318

  Fly   320 LAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVW 384
            |||:|.|..|:||:|...||::|..:.:.:|..:...|..| |.:| ....:.:...:|.||:.|
  Fly   319 LAPLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRS-TVNP-LPGGQLKKSAFRVSKNAW 381

  Fly   385 YSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGTSDRIATT 449
            .:.:.:.|...:...|.||||||....|..||.|||:||.:|.|.|......:......:||||.
  Fly   382 LAYESHPTMVGMLRDLKDATGLDTTFCEQLQVANYGVGGHYEPHWDFFRDPNHYPAEEGNRIATA 446

  Fly   450 LFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSKWIN 514
            :|||:||.|||.|.||.|::.|.||.|:.||||||....:....:.|.||||:.||||:.:.||:
  Fly   447 IFYLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVLKGSKWIGNVWIH 511

  Fly   515 DMGQEFTRPC 524
            ::.|.|.|||
  Fly   512 EVTQTFARPC 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	29/132 (22%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:433202	13/80 (16%)
		NrfG	217..>260	CDD:443378	7/43 (16%)
		TPR repeat	219..249	CDD:276809	4/30 (13%)
		P4Hc	342..513	CDD:214780	64/170 (38%)
PH4alphaNE1	NP_733374.1	P4Ha_N	26..157	CDD:462433	29/132 (22%)
		P4Hc	341..511	CDD:214780	65/171 (38%)