Protein Alignment PH4alphaNE2 and PH4alphaMP

DIOPT Version :9

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_524594.2
• Gene: PH4alphaMP / 43624
• FlyBaseID: FBgn0026190
• Length: 535
• Species: Drosophila melanogaster
• Alignment Length: 562
• Identity: 154/562 - (27%)
• Similarity: 255/562 - (45%)
• Gaps: 81/562 - (14%)

  Fly     1 MLFWRLVLLGMLYLSLSFGQLRENNA--QQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAK 63
            ||..:.||..:|.:....|:...:.:  .:.|...||.:.::.|    .|:.:.:.||||..:..
  Fly     1 MLLAKCVLFLVLQVLSCHGEFFSSTSGLAKLFETEVVLLAELQN----YVNEINQHAEALQSEID 61

  Fly    64 TIKWGVFKMMKRRQEYKSSM----EIFANPIDTFSLIRHMQSNWLMW----------LLYLETPV 114
            .|          |.|:.::.    :...||::.|.||:.:.|:|..:          ..||:|..
  Fly    62 AI----------RVEHLNAADGIDDYLNNPVNAFRLIKRLHSDWETFEGSVTADSSRSNYLDTMA 116

  Fly   115 G-QEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAI 178
            . :|.|.|        |...||:.:|..:.::|.|||:..:::|.|:|:||:|.:::...||..:
  Fly   117 SLKENLSF--------PSQDDFVGSAIALTRLQQTYQLDVAELASGILNGVKYGTAMSWQDCFVL 173

  Fly   179 GLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAY 243
            |.||.....:.....|:..|::...::|..::...|      |....:.:...:...||.||...
  Fly   174 GQHLYALRDYNHTVPWLQQSMQLLGEQSYGSESASL------DFMEAVVEYHREMGAHESALSLV 232

  Fly   244 QVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNS-------------HE----RLVLPP 291
            ...|.:.|.     :...:||.|    ..:|.:..|.|.:             ||    |:....
  Fly   233 NHVLSIEPD-----QRSHLLEAR----QQLEELITDGDKNGLLHLTARRPGDYHESREFRMYEQV 288

  Fly   292 CCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEH 356
            |......:|....||.|   .:....|..||.|.|.|.:||.||.||.:|..|:|..::.:::..
  Fly   289 CRGELAPLPSKQRNLRC---RLRKSRLGYAPFKLEELHLDPLVVQLHQVIGSKDSDSLQKTARPR 350

  Fly   357 MLPSATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGL 421
            :..|.......:...|.. .:|||:...::...|..||.::..:||.:||:|:..|..||.|||:
  Fly   351 IKRSTVYSLGGNGGSTAA-AFRTSQGASFNYSRNAATKLLSRHVGDFSGLNMDYAEDLQVANYGI 414

  Fly   422 GGFFETHLDML----LSEKNRFNGTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWY 482
            ||.:|.|.|..    :.::...:|  :|:||.::||.:|..||||.||.|.|.|.|:.||.||||
  Fly   415 GGHYEPHWDSFPENHIYQEGDLHG--NRMATGIYYLADVEAGGGTAFPFLPLLVTPERGSLLFWY 477

  Fly   483 NLDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPC 524
            ||...|:....:.|..|||:.||||:.:.||.:..|:..|||
  Fly   478 NLHPSGDQDFRTKHAACPVLQGSKWIANVWIRERNQDNVRPC 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	34/142 (24%)
		TPR repeat	175..200	CDD:276809	6/24 (25%)
		TPR_16	176..254	CDD:290168	14/77 (18%)
		TPR repeat	219..249	CDD:276809	6/29 (21%)
		TPR_2	220..253	CDD:285020	7/32 (22%)
		P4Hc	342..513	CDD:214780	60/174 (34%)
PH4alphaMP	NP_524594.2	P4Ha_N	24..156	CDD:285528	35/153 (23%)
		P4Hc	336..509	CDD:214780	61/175 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461827
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900