Protein Alignment PH4alphaNE2 and PH4alphaSG2

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_651801.1
• Gene: PH4alphaSG2 / 43623
• FlyBaseID: FBgn0039779
• Length: 527
• Species: Drosophila melanogaster
• Alignment Length: 567
• Identity: 157/567 - (27%)
• Similarity: 267/567 - (47%)
• Gaps: 76/567 - (13%)

  Fly     1 MLFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTI 65
            ||....:.:|:..|.:..|.     |...|..||.:|.|:..:|::|::......|:..::....
  Fly     1 MLDRHCLYIGIFQLIIWVGV-----ANGEFYSSVDSMQDLAQVEEELLNATRSYVESQQKQLDFY 60

  Fly    66 KWGVFKMMKRRQEYKSSM----EIFANPIDTFSLIRHMQSNW--LMWLLYLETPVGQEELFFVD- 123
            :..| :.:||..|:.:|.    :...:|:..|.||:.:..:|  |::...|.....:|...||:
  Fly    61 RRYV-EQIKREHEWATSQLKLDDYLGHPLHAFRLIKRLVRDWDSLIFEPILANNAREEFRAFVEV 124

  Fly   124 -SRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSR 187
             ||....|...:...|.:|:.::|..|.:.:||:|.|::.|:.|.|.|:..:|..||:.|.:...
  Fly   125 LSRDLGYPDQSELQGAIKGLARLQKVYNLATSDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGE 189

  Fly   188 WYAAEQWISASI--------EAYD---------QKSSQTDMELLRGPKLADLCRILGQVQMKQRN 235
            :..:.:|:..:.        |..|         :.:|..:.| |..||.|  .|:|.|:...|..
  Fly   190 YQRSLEWLQVAFILLRNSPREEKDADHYLSDIREYASMANFE-LGNPKKA--ARLLSQILESQPT 251

  Fly   236 HEGALQAYQVALKLSPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGRCQVP 300
            |             |....:.|.|.|:..|      :::..:....:::.||     |.|| ::|
  Fly   252 H-------------SAQQTQKYLESRVPGK------NVQETKPSWFSNYTRL-----CQGR-RLP 291

  Fly   301 RNLSN--LYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKE-STLIRTSSKEHMLPSAT 362
            ...|.  |.|..:.....:..|||::.|.:.:||.:.:.|.|:|.|: .::...:.||.|:.||.
  Fly   292 EERSGDPLRCYLDGKRHAYFTLAPLQVEPVHLDPDINVYHGMLSSKQILSIFEEADKEEMVRSAV 356

  Fly   363 TDPDASDDETQVDTYRTSKSVW--YSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFF 425
            .   .|..|..|...|.|:..|  |.|...::..:|.:.:   :|.||...|..||.|||:||.:
  Fly   357 A---GSGGEGTVRDLRVSQQTWLDYKSPVMNSVGRIIQFV---SGFDMAGAEHMQVANYGVGGQY 415

  Fly   426 ETHLDML-LSEKNRFNGTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGN 489
            |.|.|.. ::....|.|  |||:|::|||::|.|||.|.|.:||:.:.|..|:.:.|:||....:
  Fly   416 EPHPDYFEVNLPKNFEG--DRISTSMFYLSDVEQGGYTVFTKLNVFLPPVKGALVMWHNLHRSLH 478

  Fly   490 DHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEVLS 536
            ....:||.|||||||||.:.:.|::...|||.|||   :|:|:...|
  Fly   479 VDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRPC---NLTSDSYKS 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	33/137 (24%)
		TPR repeat	175..200	CDD:276809	5/32 (16%)
		TPR_16	176..254	CDD:433202	18/94 (19%)
		NrfG	217..>260	CDD:443378	10/42 (24%)
		TPR repeat	219..249	CDD:276809	6/29 (21%)
		P4Hc	342..513	CDD:214780	63/174 (36%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..165	CDD:462433	33/137 (24%)
		CpoB	<178..263	CDD:441335	19/100 (19%)
		P4Hc	335..503	CDD:214780	64/175 (37%)