DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and CG32199

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_730347.1	Gene:	CG32199 / 40028	FlyBaseID:	FBgn0052199	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	535	Identity:	147/535 - (27%)
Similarity:	252/535 - (47%)	Gaps:	68/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKW-------GVFKMMKRRQEYKSSMEIFA 87
            ::.||::|..:|.:|:.|.:|::...:.:..|...||.       .....::.::||.|
  Fly     3 YSTSVMSMMKLLEMEESLKTNLDIYVQEMQSKLDLIKLYQDSLKRVTLTTLEEKEEYVS------ 61

  Fly    88 NPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATYQMF 152
            ||::.|.::|.:..:|..||.|::..:..:::..::.::...|...|...|.:|:.:::..:.:.
  Fly    62 NPLNAFPMLRRLNQDWPKWLRYIKLAIASKKIKEMEVQLKSAPIDDDLKVALKGMTRIEKFHNLH 126

  Fly   153 SSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRGP 217
            :.|:.||:|.|.:.||.|...||:|:|.:..|.:::..:..|...::..:..            |
  Fly   127 AEDLTKGVLMGKKLNSHLTAPDCVALGDYYYNQTQFSGSTHWYRMALRVHTH------------P 179

  Fly   218 KLADLCRILGQVQMK-QRNHEGALQAYQVALKLSPHDPEIYEEYRILEKR--------------D 267
            :.....::||..:.: .:.:..||....:....|...|....|:..|.|.              |
  Fly   180 RGMIYAKVLGLKRKRIYKKYAKALLKESLNSDKSKPTPTEKSEWNRLAKEVTREDNYDNVKKLID 244

  Fly   268 LTLSDIEPIEQD-------KDNSHERLVLPPCCSGRCQVPRNLS-NLYCVYNHVTSPFLQLAPIK 324
            ..||..|.|.|:       |....||     .|.|  :.|:..| .|.|.||..||.||:|||:|
  Fly   245 EYLSGDEKIFQEVAARLKRKPTKLER-----GCRG--EWPKKSSPELICRYNRDTSAFLKLAPLK 302

  Fly   325 TEILSIDPFVVLLHDMISQKESTLIRTSSKEH--MLPSAT-TDPDASDDETQVDTYRTSKSVWYS 386
            .|.||:.|.::|.||::.:.|...:|..:..:  |:...| .|.|...:..|.|  |..|.:.:.
  Fly   303 LEFLSVQPMILLYHDVLYENEFKSMRDIAMYNGSMIDGWTYVDFDKKGNPKQQD--RVVKMIAFQ 365

  Fly   387 SDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKN------RFNGTSDR 445
            ......|..|..|:.|.:||:|.......:.||||||.|..|:|.:...|.      .|.|  ||
  Fly   366 GTTAPFTLSINRRMADMSGLEMRDNMVLYLTNYGLGGHFGKHVDYVELAKRPPDFFADFGG--DR 428

  Fly   446 IATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMS 510
            |||.|.|.:::..||.|.|.:|.:.|.|:.||||.|:||:..|.....:.|:.|||::||:|::|
  Fly   429 IATALIYASDIPLGGTTVFTKLKIAVQPKKGSALIWFNLNHAGEPDPLTEHSVCPVVLGSRWIIS 493

  Fly   511 KWINDMGQEFTRPCV 525
            |||::..|.|.:||:
  Fly   494 KWIHERQQVFKKPCL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	28/134 (21%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:290168	10/78 (13%)
		TPR repeat	219..249	CDD:276809	4/30 (13%)
		TPR_2	220..253	CDD:285020	5/33 (15%)
		P4Hc	342..513	CDD:214780	60/179 (34%)
CG32199	NP_730347.1	P4Ha_N	6..135	CDD:285528	28/134 (21%)
CG32199	NP_730347.1	P4Hc	<369..497	CDD:214780	51/129 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461982
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910