Protein Alignment PH4alphaNE2 and CG18231

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_649045.2
• Gene: CG18231 / 40026
• FlyBaseID: FBgn0036796
• Length: 470
• Species: Drosophila melanogaster
• Alignment Length: 534
• Identity: 135/534 - (25%)
• Similarity: 227/534 - (42%)
• Gaps: 100/534 - (18%)

  Fly    23 ENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKM-MKRRQEYKSSMEIF 86
            |||:   ...|:..:..:|.:|:..::|::.....||.|.|.::..:..: .:.:|.::...:..
  Fly    12 ENNS---VYSSITRLLKLLEMEEIFITNIKAYTNKLAEKVKNLQAYIDSVDYEFQQSFEDREKYV 73

  Fly    87 ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATYQM 151
            .|||:.|||:|....:...|..|.:..||.||||.::..:..:|...|...:...:.:::..|.:
  Fly    74 GNPINAFSLVRRTHQDLPKWHNYSQQIVGMEELFALEEIIAKVPDKKDMAYSLGEMHRIEQIYDL 138

  Fly   152 FSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQKSSQTDMELLRG 216
            .:.::|:|.:.|.||:......||:|:|.|......:..|..|...:|:...:.:::....:|..
  Fly   139 EAIELARGRIQGKQYDFRPSIRDCVALGEHKFKREDYQRASMWFRVAIKHEPEGNAEIINSILGD 203

  Fly   217 PKL------ADLCRILGQV---------QMKQRNHEGALQAYQVALK------LSPHDPEIYEEY 260
            ||:      |....|.|.:         :.|:.::|...:|....:|      ||..|.||..|.
  Fly   204 PKVNLYTLYAKSMLIFGMIKSNPSMTIAEAKKISYEALNKASLADIKSLLNELLSQTDDEIVYEM 268

  Fly   261 RILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGRCQVPRNLSNLYCVYNHVTSPFLQLAPIKT 325
            .              :.:.|.:.:|     ..|.|:....|   |..|.||...:.||:|||:|.
  Fly   269 N--------------VNKTKPSDYE-----IGCRGQFLRRR---NHVCTYNFTITEFLKLAPLKQ 311

  Fly   326 EILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDFN 390
            |:|:.||::|:.||:::..|...:    |.|:     .|.||                   .:.|
  Fly   312 EVLNWDPYIVIYHDVLNDDEIDKL----KNHL-----NDTDA-------------------VEVN 348

  Fly   391 DTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGTSDRIATTLFYLNE 455
            ...|:|.:|:.:.|.|....::...|...|.    .||    ..:|....|      |.||:||.
  Fly   349 PIEKRIFQRINELTRLSFEHSDQQIVSKNGP----RTH----KHKKEYLKG------TLLFFLNN 399

  Fly   456 VRQGGGTYFPRLNLTVFPQPGSALFWYN-LDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQE 519
            |..||...||:|.::||||.||.|||:| ||.:      |....|||:.|:|.|    |...|..
  Fly   400 VELGGAMVFPKLKISVFPQKGSCLFWHNTLDPR------SEPLECPVLQGNKRV----ITQKGAY 454

  Fly   520 FTRPCVESSLSSNE 533
            ..||.......||:
  Fly   455 NGRPMQYKKAKSNQ 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	29/130 (22%)
		TPR repeat	175..200	CDD:276809	6/24 (25%)
		TPR_16	176..254	CDD:433202	18/98 (18%)
		NrfG	217..>260	CDD:443378	14/63 (22%)
		TPR repeat	219..249	CDD:276809	7/50 (14%)
		P4Hc	342..513	CDD:214780	48/171 (28%)
CG18231	NP_649045.2	P4Ha_N	19..150	CDD:462433	29/130 (22%)
		2OG-FeII_Oxy	322..449	CDD:473886	50/178 (28%)