DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and p4ha2

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	554	Identity:	159/554 - (28%)
Similarity:	264/554 - (47%)	Gaps:	60/554 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKMM 73
            |..|..:|||    .:..:.....|:..|.:::..|.:||.::::..:|..:|.:|::....|:.
Zfish     5 LVFLLSTLSF----SSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLD 65

  Fly    74 KRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYF---- 133
            |..:...|..|.| |:|::.:.|::.:.:.|    ..||:.|.|:......|.|.:..:||
Zfish    66 KLTRTSTSDPEGFLAHPVNAYKLMKRLNTEW----SELESLVLQDPSDGFISNMSVHRQYFPDEE 126

  Fly   134 DFIDAAEGIRKMQATYQMFSSDIAKGLL------DGVQYNSSLKPIDCLAIGLHLMNNSRWYAAE 192
            |...||:.:.::|.||::.:...:||.|      .||:||:.|...||..:|....|::.:|.:.
Zfish   127 DEKGAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSV 191

  Fly   193 QWISASIEAYDQ----KSSQTDM---------ELLRGPKLADLCRILGQVQMKQRNHEGALQAYQ 244
            .|:..|:...|.    |:.:.|:         ::...|:..:|.|.|..:....:...|.|:.::
Zfish   192 LWMQQSLRQMDSGEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFE 256

  Fly   245 VALKLSPHD-----PEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPCCSGR--CQVPRN 302
            ..|.....|     ||..:|..|         .::..::.||...||......|.|.  ....:.
Zfish   257 RLLSKELQDSGQTQPEPADERPI---------QLDTYQRPKDYLPEREAYEALCRGEGVKMTTKR 312

  Fly   303 LSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPD 366
            .|.|:|.|.... :|.|.|.|:|.|.....|.:|...:.:|.:|...|:..:...:..:...||
Zfish   313 QSRLFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDP- 376

  Fly   367 ASDDETQVDT---YRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETH 428
                :|.|.|   ||.|||.|...:.:....::.:|:.|.|||.:::.|..||.|||:||.:|.|
Zfish   377 ----KTGVLTVAHYRVSKSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPH 437

  Fly   429 LDM-LLSEKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGND 490
            .|. ...|.:.|.  ||.:|:||.|.|:::|..||.|.||....:|:|:.|:|:|||||...|..
Zfish   438 FDFSRKDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEG 502

  Fly   491 HMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPC 524
            ...:.|..|||:||||||.:|||::.||||.|||
Zfish   503 DYRTRHAACPVLVGSKWVSNKWIHERGQEFRRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	33/132 (25%)
		TPR repeat	175..200	CDD:276809	6/24 (25%)
		TPR_16	176..254	CDD:290168	16/95 (17%)
		TPR repeat	219..249	CDD:276809	6/29 (21%)
		TPR_2	220..253	CDD:285020	6/32 (19%)
		P4Hc	342..513	CDD:214780	66/176 (38%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	33/132 (25%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	67/177 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820