DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and P4ha3

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	126/522 - (24%)
Similarity:	213/522 - (40%)	Gaps:	121/522 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DDLVSNVEKLAEALARKAKTIKWGVFKMMKRRQE---------YKSSMEI-------FANPIDTF 93
            :|..|.:..:|.|||.:.:.:  |..:...|.:|         |...:.:       ..||:..|
  Rat    28 EDTFSALTSVARALAPERRLL--GTLRRYLRGEEARLRDLTRFYDKVLSLHEDLKIPVVNPLLAF 90

  Fly    94 SLIRHMQSNWLMWLLYLET------------PVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQ 146
            :||:.:||:|...:..||.            .|.|:           ||.:.|...||..:.::|
  Rat    91 TLIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQD-----------LPAFEDLEGAARALMRLQ 144

  Fly   147 ATYQMFSSDIAKGLLDGVQYNS-----------SLKPIDCLAIGLHLMNNSRWYAAEQWISASIE 200
            ..|.:....:|:|:...|..:|           ||...||..:|....:...:|.|..|:..::.
  Rat   145 DVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVS 209

  Fly   201 AY----------DQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPE 255
            .:          |:.|.:..::.     ||..|..:|.|..       ||...:..|..||.:..
  Rat   210 LFRRSYGEWKTEDEASLEDALDY-----LAFACYQVGNVSC-------ALSLSREFLVYSPDNKR 262

  Fly   256 I------YEEYRILEKRDLTLSDIEPIE-------QDKDNSHERLVLPPCCSGRCQV----PRN- 302
            :      ||  |:|.:....::....|:       |.:| ::|         |.||.    |.:
  Rat   263 MARNVLKYE--RLLAENGHLMAAETAIQRPNVPHLQTRD-TYE---------GLCQTLGSQPTHY 315

  Fly   303 -LSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPD 366
             :.:|||.|...:||:|.|.|.:.|::.:.|.|.|.||.:|.:|:..||..::..:..|...
  Rat   316 QIPSLYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVA--- 377

  Fly   367 ASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNS--TEFYQVINYGLGGFFETHL 429
            :.:.:.||: ||.|||.|.....:.....:..|:...||||:..  .|:.||:|||:||.:|.|.
  Rat   378 SGEKQLQVE-YRISKSAWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHF 441

  Fly   430 DMLLSEKNRF--NGTSDRIATTLFYLNEVRQGGGTYFPRLNLTV----FPQPGSALFWYNLDTKG 488
            |...|..:..  ..:.:|:||.:.||:.|..||.|.|...|.:|    :|..|    :.::|...
  Rat   442 DHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSVPVVKWPTSG----YTSMDRNS 502

  Fly   489 ND 490
            .|
  Rat   503 ED 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	31/143 (22%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:290168	16/87 (18%)
		TPR repeat	219..249	CDD:276809	8/29 (28%)
		TPR_2	220..253	CDD:285020	9/32 (28%)
		P4Hc	342..513	CDD:214780	46/157 (29%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	16/75 (21%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	39/125 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850