Protein Alignment PH4alphaNE2 and P4ha3

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: XP_063123241.1
• Gene: P4ha3 / 361612
• RGDID: 735150
• Length: 584
• Species: Rattus norvegicus
• Alignment Length: 499
• Identity: 122/499 - (24%)
• Similarity: 205/499 - (41%)
• Gaps: 113/499 - (22%)

  Fly    45 DDLVSNVEKLAEALARKAKTIKWGVFKMMKRRQE---------YKSSMEI-------FANPIDTF 93
            :|..|.:..:|.|||.:.:.:  |..:...|.:|         |...:.:       ..||:..|
  Rat    28 EDTFSALTSVARALAPERRLL--GTLRRYLRGEEARLRDLTRFYDKVLSLHEDLKIPVVNPLLAF 90

  Fly    94 SLIRHMQSNWLMWLLYLET------------PVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQ 146
            :||:.:||:|...:..||.            .|.|:           ||.:.|...||..:.::|
  Rat    91 TLIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQD-----------LPAFEDLEGAARALMRLQ 144

  Fly   147 ATYQMFSSDIAKGLLDGVQYNS-----------SLKPIDCLAIGLHLMNNSRWYAAEQWISASIE 200
            ..|.:....:|:|:...|..:|           ||...||..:|....:...:|.|..|:..::.
  Rat   145 DVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDYYHAIPWLEEAVS 209

  Fly   201 AY----------DQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPE 255
            .:          |:.|.:..::.     ||..|..:|.|..       ||...:..|..||.:..
  Rat   210 LFRRSYGEWKTEDEASLEDALDY-----LAFACYQVGNVSC-------ALSLSREFLVYSPDNKR 262

  Fly   256 I------YEEYRILEKRDLTLSDIEPIE-------QDKDNSHERLVLPPCCSGRCQV----PRN- 302
            :      ||  |:|.:....::....|:       |.:| ::|         |.||.    |.:
  Rat   263 MARNVLKYE--RLLAENGHLMAAETAIQRPNVPHLQTRD-TYE---------GLCQTLGSQPTHY 315

  Fly   303 -LSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPD 366
             :.:|||.|...:||:|.|.|.:.|::.:.|.|.|.||.:|.:|:..||..::..:..|...
  Rat   316 QIPSLYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRELAEPWLQRSVVA--- 377

  Fly   367 ASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNS--TEFYQVINYGLGGFFETHL 429
            :.:.:.||: ||.|||.|.....:.....:..|:...||||:..  .|:.||:|||:||.:|.|.
  Rat   378 SGEKQLQVE-YRISKSAWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVVNYGIGGHYEPHF 441

  Fly   430 DMLLSEKNRF--NGTSDRIATTLFYLNEVRQGGGTYFPRLNLTV 471
            |...|..:..  ..:.:|:||.:.||:.|..||.|.|...|.:|
  Rat   442 DHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSV 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	31/145 (21%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:433202	16/87 (18%)
		NrfG	217..>260	CDD:443378	12/48 (25%)
		TPR repeat	219..249	CDD:276809	8/29 (28%)
		P4Hc	342..513	CDD:214780	42/134 (31%)
P4ha3	XP_063123241.1	None