Protein Alignment PH4alphaNE2 and P4ha2

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_001101745.1
• Gene: P4ha2 / 360526
• RGDID: 1309673
• Length: 535
• Species: Rattus norvegicus
• Alignment Length: 553
• Identity: 168/553 - (30%)
• Similarity: 257/553 - (46%)
• Gaps: 63/553 - (11%)

  Fly     9 LGMLYLSLS-FGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKM 72
            |.:|.|.:| ||.|  :..|..|..|:.:|.|::..|.|||.::::...|...|...||....||
  Rat     3 LQVLVLLMSWFGVL--SWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKM 65

  Fly    73 MKRRQEYKSSME-IFANPIDTFSLIRHMQSNW--LMWLLYLETPVG-------QEELFFVDSRMP 127
            .....:..:..| ..|:|::.:.|::.:.::|  |..|:..:...|       |.:.|..|.
  Rat    66 EALTSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDE--- 127

  Fly   128 LLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAE 192
                  |...||..:.::|.||::....|::|.|.|.:|.:.|...||..:|....|...:|...
  Rat   128 ------DESGAARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTV 186

  Fly   193 QW-------ISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQR------NHE---GALQ 241
            .|       :.|..||...||...|.......:|.||.|   .|::.:|      :||   |.|:
  Rat   187 LWMEQVLKQLDAGEEATVTKSLVLDYLSYAVFQLGDLHR---AVELTRRLLSLDPSHERAGGNLR 248

  Fly   242 AYQVALKLSPHDPEIYEEYR---ILEKRDLTLSDIEPI-EQDKDNSHERLVLPPCCSGR--CQVP 300
            .::          .:.||.|   :..:.|..|:..|.: |:..|...||.|....|.|.  ...|
  Rat   249 YFE----------RLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTP 303

  Fly   301 RNLSNLYCVYNHVTS-PFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTD 364
            |....|:|.|:|... |.|.:||.|.|.....|.:|..:|::|.:|...|:..:|..:..:...|
  Rat   304 RRQKRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRD 368

  Fly   365 PDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHL 429
            |...  ...|.:||.|||.|...|.:....::..|:...|||.:.:.|..||.|||:||.:|.|.
  Rat   369 PKTG--VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHF 431

  Fly   430 DMLLS-EKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDH 491
            |...| |::.|.  ||.:|:||.|.|:::|..||.|.||.|...::|:.|:|:|||||...|...
  Rat   432 DFSRSDERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGD 496

  Fly   492 MGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPC 524
            ..:.|..|||:||.|||.:||.::.||||.|||
  Rat   497 YRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	33/139 (24%)
		TPR repeat	175..200	CDD:276809	6/31 (19%)
		TPR_16	176..254	CDD:433202	20/93 (22%)
		NrfG	217..>260	CDD:443378	11/51 (22%)
		TPR repeat	219..249	CDD:276809	10/38 (26%)
		P4Hc	342..513	CDD:214780	65/173 (38%)
P4ha2	NP_001101745.1	P4Ha_N	26..157	CDD:462433	33/139 (24%)
		P4Hc	346..519	CDD:214780	66/174 (38%)