DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and CG31016

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001263119.1	Gene:	CG31016 / 326113	FlyBaseID:	FBgn0051016	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	163/527 - (30%)
Similarity:	248/527 - (47%)	Gaps:	45/527 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARK-------AKTIKWGVFKMMKRRQEYKSSME 84
            :|.:..||....|:|..:.:|:..::..|..|..|       .|..|..:.|...|.:||.|
  Fly    25 RQNYVISVEEKMDLLEKDRELIIVLDSYATELNEKIIMLKRIVKEFKQPLEKAKNREEEYLS--- 86

  Fly    85 IFANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQATY 149
               ||||:.||:|.|..:|......|:.|||||::..|:.....||...|.::|.:.:.::..||
  Fly    87 ---NPIDSLSLMRQMHEDWEKVEKLLKKPVGQEKIALVEKMREDLPVENDLMEANQAMFRILHTY 148

  Fly   150 QMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQWISASIE-AYDQKSSQTDMEL 213
            .:...|::.|.:|||||...:...||..:|........:..|.:|:||:.: ..||.....:
  Fly   149 DLEPKDVSAGWIDGVQYGGKMSASDCFTMGTFSFMAGSYQIASKWLSAAKDLLVDQPRKYHE--- 210

  Fly   214 LRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYE-----EYRILEKRDLTLSDI 273
            :.|...||:..:|.:..:...|       ..:|..:...|....|     ....|..:.....::
  Fly   211 VMGITKADVTLLLARSLIASGN-------VSIATDMLMRDFMFGEAGSALTVHFLRNKPKPSINL 268

  Fly   274 EPIEQDKDNSHERLVLPPC-CSGRCQVPRNL-SNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVL 336
            |..|.|:  |..:|    | .|.|.|:..:. |.|:|.||.:|:|||:|||.:.|.||:||:|:.
  Fly   269 ESWESDE--SFNQL----CRSSSRRQMGESKPSRLHCRYNTITTPFLKLAPFRMEELSLDPYVIF 327

  Fly   337 LHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVW-----YSSDFNDTTKKI 396
            .|:::|..|...::...|..:..:.....:...||  :|..|::...|     ...|..:...:|
  Fly   328 YHNVLSDAEIEKLKPMGKPFLERAKVFRVEKGSDE--IDPSRSADGAWLPHQNIDPDDLEVLNRI 390

  Fly   397 TERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGTSDRIATTLFYLNEVRQGGG 461
            ..|:.|.|||:..|....|.:.||.||.|..|.|...|:........|||||.|||||.|..||.
  Fly   391 GRRIEDMTGLNTRSGSKMQFLKYGFGGHFVPHYDYFNSKTFSLETVGDRIATVLFYLNNVDHGGA 455

  Fly   462 TYFPRLNLTVFPQPGSALFWYNLDTKGNDH-MGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCV 525
            |.||:|||.|..|.||||||:|:|.|..|: ..:.|..||:|.|:|.||::||.::.|.|..|.|
  Fly   456 TVFPKLNLAVPTQKGSALFWHNIDRKSYDYDTRTFHGACPLISGTKLVMTRWIYELDQMFLIPAV 520

  Fly   526 ESSLSSN 532
            ....|.|
  Fly   521 LPPRSRN 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	39/134 (29%)
		TPR repeat	175..200	CDD:276809	6/24 (25%)
		TPR_16	176..254	CDD:290168	13/78 (17%)
		TPR repeat	219..249	CDD:276809	5/29 (17%)
		TPR_2	220..253	CDD:285020	5/32 (16%)
		P4Hc	342..513	CDD:214780	64/176 (36%)
CG31016	NP_001263119.1	P4Ha_N	31..160	CDD:285528	39/134 (29%)
CG31016	NP_001263119.1	P4Hc	333..508	CDD:214780	64/176 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461913
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28396
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.910