Protein Alignment PH4alphaNE2 and PH4alphaSG1

DIOPT Version :9

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_733376.1
• Gene: PH4alphaSG1 / 326112
• FlyBaseID: FBgn0051014
• Length: 540
• Species: Drosophila melanogaster
• Alignment Length: 535
• Identity: 147/535 - (27%)
• Similarity: 245/535 - (45%)
• Gaps: 60/535 - (11%)

  Fly    33 SVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGVFKMMKRRQEYKSSMEIFANPIDTFSLIR 97
            ::..::.:|::|..:|...::..|...::.:.:|..:.::.:::.:.....|.|.|||:.|..|:
  Fly    23 AISELERLLDVEAFIVEKFDEYLERAQQEQENLKRFLDQIDEQQNDRGDLEEYFGNPINAFITIK 87

  Fly    98 HMQSNWLMWLLYLETPVGQEELF------FVDSRMPLL---PKYFDFIDAAEGIRKMQATYQMFS 153
            .:..:|...:.   .||.....|      ..||...:.   |...|...|...:.::|..||:.:
  Fly    88 RLVHDWKFNVF---DPVFDSSNFETYKNNLSDSLEKINFKGPTQEDLHGATRALLRLQNMYQLNT 149

  Fly   154 SDIAKGLLDGVQYN---SSLKPIDCLAIGLHLMNNSRWYAAEQWISASIEAYDQ---------KS 206
            ..:|.|:|...:.|   :||...||..:|.:|.....:....:|:   :||..:         ..
  Fly   150 DHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWL---LEARKRLHGKPLGFISP 211

  Fly   207 SQTDMELLRGPKLADLCRILGQVQM----------KQRNHEGALQAYQVALKLSPHDPEIYEEYR 261
            :.:|:|:|.  .|:.....||.:::          |:.:||.||:           :..:||...
  Fly   212 NVSDVEILE--HLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALK-----------NKILYEGQL 263

  Fly   262 ILEKRDLTLSDIE-PIEQDKDNSHERLVLPPCCSGRC-QVPRNLSNLYCVYNHVTSPFLQLAPIK 324
            ..|:.......:| |...:|:......:....|.|.. |.||...||.|...|...|:.:|:|.|
  Fly   264 ARERSFAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWLYHQGVPYYRLSPFK 328

  Fly   325 TEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVWYSSDF 389
            .|.|::||:|..:|:::...|...|....|.:|..|..    ...:.:.....|.|::.|...|.
  Fly   329 IEQLNVDPYVAYVHEVLWDSEIDTIMEHGKGNMERSKV----GQSENSTTSEVRISRNTWLWYDA 389

  Fly   390 NDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSE-KNRFNGTSDRIATTLFYL 453
            |....||.:||.|.|||...|.|..|::|||:||.:|.|.|.:..: ::.|:...:|:.|.||||
  Fly   390 NPWLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFSWKGNRLLTALFYL 454

  Fly   454 NEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQ 518
            |:|..||.|.||.|.|.|.|..||.|.||||.:..:....:.|.||||:.||||:.::|.:...|
  Fly   455 NDVALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKWICNEWFHVGAQ 519

  Fly   519 EFTRPCVESSLSSNE 533
            ||.|||   .|||:|
  Fly   520 EFRRPC---GLSSDE 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	26/136 (19%)
		TPR repeat	175..200	CDD:276809	4/24 (17%)
		TPR_16	176..254	CDD:290168	16/96 (17%)
		TPR repeat	219..249	CDD:276809	8/39 (21%)
		TPR_2	220..253	CDD:285020	7/42 (17%)
		P4Hc	342..513	CDD:214780	63/171 (37%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	26/136 (19%)
		P4Hc	347..515	CDD:214780	64/171 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461954
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	1	0.950	-	0	Normalized mean entropy	S4458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	11	10.850