Protein Alignment PH4alphaNE2 and P4HA3

DIOPT Version :9

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 482
• Identity: 119/482 - (24%)
• Similarity: 202/482 - (41%)
• Gaps: 81/482 - (16%)

  Fly    46 DLVSNVEKLAEALARKAKTIKWGVFKMMKRRQE----------------YKSSMEIFANPIDTFS 94
            |..|.:..:|.|||.:.:.:  |:.:...|.:|                ::.|....|||:..|:
Human    29 DTFSALTSVARALAPERRLL--GLLRRYLRGEEARLRDLTRFYDKVLSLHEDSTTPVANPLLAFT 91

  Fly    95 LIRHMQSNWLMWLLYLET------------PVGQEELFFVDSRMPLLPKYFDFIDAAEGIRKMQA 147
            ||:.:||:|...:..||.            .|.|:           ||.:.|...||..:.::|.
Human    92 LIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQD-----------LPAFEDLEGAARALMRLQD 145

  Fly   148 TYQMFSSDIAKGLLDGVQYNS-----------SLKPIDCLAIGLHLMNNSRWYAAEQWISASIEA 201
            .|.:....:|:|:...|..::           ||...||..:|....:...:|.|..|:..::..
Human   146 VYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVSL 210

  Fly   202 YDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEIYEEYRILEKR 266
            :  :.|..:.:......|.|....|.....:..|...||...:..|..||.:..:   .|.:.|.
Human   211 F--RGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRM---ARNVLKY 270

  Fly   267 DLTLSD------IEPIEQDKDNSHERLVLPPCCSGRCQV----PR--NLSNLYCVYNHVTSPFLQ 319
            :..|::      .|.:.|..:..|  |.......|.||.    |.  .:.:|||.|...::.:|.
Human   271 ERLLAESPNHVVAEAVIQRPNIPH--LQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNAYLL 333

  Fly   320 LAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYRTSKSVW 384
            |.||:.|::.::|::.|.||.:|..|:..||..::..:..|...   :.:.:.||: ||.|||.|
Human   334 LQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVA---SGEKQLQVE-YRISKSAW 394

  Fly   385 YSSDFNDTTKKITERLGDATGLDMNS--TEFYQVINYGLGGFFETHLDMLLSEKN---RFNGTSD 444
            .....:.....:..|:...||||:..  .|:.||:|||:||.:|.|.|...|..:   |.. :.:
Human   395 LKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYEPHFDHATSPSSPLYRMK-SGN 458

  Fly   445 RIATTLFYLNEVRQGGGTYFPRLNLTV 471
            |:||.:.||:.|..||.|.|...||:|
Human   459 RVATFMIYLSSVEAGGATAFIYANLSV 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	32/142 (23%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:290168	14/77 (18%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		TPR_2	220..253	CDD:285020	8/32 (25%)
		P4Hc	342..513	CDD:214780	44/135 (33%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	24/111 (22%)
		TPR_12	186..252	CDD:290160	11/67 (16%)
		P4Hc	356..>478	CDD:214780	40/126 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.800