Protein Alignment PH4alphaNE2 and P4ha2

DIOPT Version :9

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: XP_006532515.1
• Gene: P4ha2 / 18452
• MGIID: 894286
• Length: 557
• Species: Mus musculus
• Alignment Length: 578
• Identity: 170/578 - (29%)
• Similarity: 260/578 - (44%)
• Gaps: 86/578 - (14%)

  Fly     5 RLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEK--LAEALARKAKTIKW 67
            :|.:|.::.|...||.|  :..|..|..|:.:|.|::..|.|||.::::  |.|. |:.||...|
Mouse     2 KLQVLVLVLLMSWFGVL--SWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILVEE-AKLAKIKSW 63

  Fly    68 GVFKMMKRRQEYKSSME-IFANPIDTFSLIRHMQSNW--LMWLLYLETPVG-------QEELFFV 122
             ..||........:..| ..|:|::.:.|::.:.::|  |..|:..:...|       |.:.|..
Mouse    64 -ASKMEALTSRSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDASAGFVANLSVQRQFFPT 127

  Fly   123 DSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSR 187
            |.         |...||..:.::|.||::....|::|.|.|.:|.:.|...||..:|....|...
Mouse   128 DE---------DESGAARALMRLQDTYKLDPDTISRGELPGTKYQAMLSVDDCFGLGRSAYNEGD 183

  Fly   188 WYAAEQW-------ISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQR------NHE-- 237
            :|....|       :.|..||...||...|.......:|.||.|   .|::.:|      :||
Mouse   184 YYHTVLWMEQVLKQLDAGEEATVTKSLVLDYLSYAVFQLGDLHR---AVELTRRLLSLDPSHERA 245

  Fly   238 -GALQAYQVALKLSPHDPEIYEEYR---ILEKRDLTLSDIEPI-EQDKDNSHERLVLPPCCSGR- 296
             |.|:.::          .:.||.|   :..:.|..|:..|.: |:..|...||.|....|.|.
Mouse   246 GGNLRYFE----------RLLEEERGKSLSNQTDAGLATQENLYERPTDYLPERDVYESLCRGEG 300

  Fly   297 -CQVPRNLSNLYCVYNHVTS-PFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLP 359
             ...||....|:|.|:|... |.|.:||.|.|.....|.:|..:|::|.:|...|:..:|..:..
Mouse   301 VKLTPRRQKKLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLAR 365

  Fly   360 SATTDPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGF 424
            :...||...  ...|.:||.|||.|...|.:....::..|:...|||.:.:.|..||.|||:||.
Mouse   366 ATVRDPKTG--VLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQ 428

  Fly   425 FETHLDM--------LLSEKNRFN---------------GTSDRIATTLFYLNEVRQGGGTYFPR 466
            :|.|.|.        |.:|.||..               ||.:|:||.|.|:::|..||.|.||.
Mouse   429 YEPHFDFSRRPFDSGLKTEGNRLATFLNYSDEQDAFKRLGTGNRVATFLNYMSDVEAGGATVFPD 493

  Fly   467 LNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPC 524
            |...::|:.|:|:|||||...|.....:.|..|||:||.|||.:||.::.||||.|||
Mouse   494 LGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPC 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	34/139 (24%)
		TPR repeat	175..200	CDD:276809	6/31 (19%)
		TPR_16	176..254	CDD:290168	20/93 (22%)
		TPR repeat	219..249	CDD:276809	10/38 (26%)
		TPR_2	220..253	CDD:285020	9/41 (22%)
		P4Hc	342..513	CDD:214780	66/193 (34%)
P4ha2	XP_006532515.1	P4Ha_N	28..157	CDD:369820	34/139 (24%)
		P4Hc	348..541	CDD:214780	67/194 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820