DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PH4alphaNE2 and P4ha1

DIOPT Version :9

Sequence 1:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001303300.1	Gene:	P4ha1 / 18451	MGIID:	97463	Length:	534	Species:	Mus musculus

Alignment Length:	559	Identity:	165/559 - (29%)
Similarity:	266/559 - (47%)	Gaps:	57/559 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LFWRLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66
            :.|.::::.:|        |.::.|...|..|:..|.|:::.|.|||::::...:|...|.:.||
Mouse     1 MIWVVLMMAIL--------LPQSLAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIK 57

  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNW--LMWLLYLETPVGQEELFFVDSRMPL 128
            ....|:.:.........|.| .:|::.|.|::.:.:.|  |..|:..:...|     |: |.:.:
Mouse    58 KWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDG-----FI-SNLTI 116

  Fly   129 LPKYF----DFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWY 189
            ..:||    |.:.||:.:.::|.||.:.::.|:||.|.|||:.|.|...||..:|......:.:|
Mouse   117 QRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYY 181

  Fly   190 AAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDP 254
            ..|.|:..::...::....|          .|...:|..:...........:|..:..||...||
Mouse   182 HTELWMEQALTQLEEGELST----------VDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDP 236

  Fly   255 E--------IYEEYRILEKRDLT------LSDIEPIEQDK----DNSHERLVLPPCCSGR--CQV 299
            |        :|.||.:.:::|..      .||.:...:.|    |...||......|.|.  ...
Mouse   237 EHQRANGNLVYFEYIMSKEKDANKSASGDQSDQKTAPKKKGIAVDYLPERQKYEMLCRGEGIKMT 301

  Fly   300 PRNLSNLYCVYNHVT-SPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATT 363
            ||....|:|.|:... :|...|||.|.|.....|.::..||:||..|..:::..:|..:..:...
Mouse   302 PRRQKRLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVH 366

  Fly   364 DPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETH 428
            ||:.....|.  .||.|||.|.|...:....:|..|:.|.||||:::.|..||.|||:||.:|.|
Mouse   367 DPETGKLTTA--QYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPH 429

  Fly   429 LDML-LSEKNRFN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGND 490
            .|.. ..|.:.|.  ||.:||||.|||:::|..||.|.||.:..:|:|:.|:|:|||||...|..
Mouse   430 FDFARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEG 494

  Fly   491 HMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSL 529
            ...:.|..|||:||:|||.:||:::.||||.|||..|.|
Mouse   495 DYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSEL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	34/134 (25%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:290168	10/77 (13%)
		TPR repeat	219..249	CDD:276809	3/29 (10%)
		TPR_2	220..253	CDD:285020	5/32 (16%)
		P4Hc	342..513	CDD:214780	68/173 (39%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	34/134 (25%)
		TPR	205..238		6/32 (19%)
		P4Hc	345..518	CDD:214780	69/174 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820