Protein Alignment PH4alphaNE2 and phy-2

DIOPT Version :10

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_502317.1
• Gene: phy-2 / 178170
• WormBaseID: WBGene00004025
• Length: 539
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 159/548 - (29%)
• Similarity: 254/548 - (46%)
• Gaps: 42/548 - (7%)

  Fly     5 RLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGV 69
            |.|||..|...|:...|         ..::.::..||..|.|:.:.:::..||...:...::...
 Worm     2 RAVLLVCLLAGLAHADL---------FTAIADLQHMLGAEKDVTTIIDQYIEAERARLDDLRRYA 57

  Fly    70 FKMMKRRQEYKS-SMEIFANPIDTFSLIRHMQSNW-LMWLLYLETPVGQEELFFVDSRM---PLL 129
            .:.:.|....:| ..|...|||:.:.||:.:.:.| .:..:.|............|:|:   ...
 Worm    58 HEYVHRNAHAESVGPEFVTNPINAYLLIKRLTTEWKKVENIMLNNKASTFLKNITDNRVRSEVKF 122

  Fly   130 PKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNNSRWYAAEQW 194
            |...|...||..:.::|.||.:.:.|::.|::.|.:.::.|...|...:|....|...:|....|
 Worm   123 PGEEDLSGAATALLRLQDTYSLDTLDLSNGIIGGEKVSNKLSGHDTFEVGRSAYNQKDYYHCLMW 187

  Fly   195 ISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLSPHDPEI--- 256
            :..::...:.::..|..|.       ::...|.....:|.|...||...:...|::|:.|..
 Worm   188 MQVALVKIENENPPTIEEW-------EILEYLAYSLYQQGNVRRALSLTKRLAKIAPNHPRAKGN 245

  Fly   257 ---YEEYRILEKRDLTLSDIEPIEQDK---DNSHERLVLPPCCSGRCQ--VPRNLSNLYCVYNHV 313
               ||:  :|:.:|: :.|:.||...:   |...||......|.|...  .|:..:.|.| |...
 Worm   246 VKWYED--MLQGKDM-VGDLPPIVNKRVEYDGIVERDAYEALCRGEIPPVEPKWKNKLRC-YLKR 306

  Fly   314 TSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTYR 378
            ..|||:|||||.|||..||..||..::|...|..:|:..:...:  ...|..::...|.:..|||
 Worm   307 DKPFLKLAPIKVEILRFDPLAVLFKNVIHDSEIEVIKELASPKL--KRATVQNSKTGELEHATYR 369

  Fly   379 TSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDML-LSEKNRFN-- 440
            .|||.|...|.:....::..|:.|.|.|:..::|..||.||||||.::.|.|.. ..|||.|.
 Worm   370 ISKSAWLKGDLDPVIDRVNRRIEDFTNLNQATSEELQVANYGLGGHYDPHFDFARKEEKNAFKTL 434

  Fly   441 GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVIVGS 505
            .|.:||||.|||:::..:||.|.|..|...|||....|||||||...|...:.:.|..|||::|.
 Worm   435 NTGNRIATVLFYMSQPERGGATVFNHLGTAVFPSKNDALFWYNLRRDGEGDLRTRHAACPVLLGV 499

  Fly   506 KWVMSKWINDMGQEFTRPC-VESSLSSN 532
            |||.:|||::.|||||||| :|..:..|
 Worm   500 KWVSNKWIHEKGQEFTRPCGLEEEVQEN 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	27/134 (20%)
		TPR repeat	175..200	CDD:276809	4/24 (17%)
		TPR_16	176..254	CDD:433202	13/77 (17%)
		NrfG	217..>260	CDD:443378	10/48 (21%)
		TPR repeat	219..249	CDD:276809	5/29 (17%)
		P4Hc	342..513	CDD:214780	64/173 (37%)
phy-2	NP_502317.1	P4Ha_N	21..156	CDD:462433	27/134 (20%)
		P4Hc	335..508	CDD:214780	65/174 (37%)