Protein Alignment PH4alphaNE2 and dpy-18

DIOPT Version :9

• Sequence 1: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_499464.1
• Gene: dpy-18 / 176569
• WormBaseID: WBGene00001077
• Length: 559
• Species: Caenorhabditis elegans
• Alignment Length: 571
• Identity: 168/571 - (29%)
• Similarity: 262/571 - (45%)
• Gaps: 74/571 - (12%)

  Fly     5 RLVLLGMLYLSLSFGQLRENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIKWGV 69
            ||.||.:..:..:...|         ..|:.:|.::|..|.::...::|.......:...:|
 Worm     2 RLALLVLATIGYAVADL---------FTSIADMQNLLETERNIPKILDKYIHDEEERLVQLK--- 54

  Fly    70 FKMMKRRQEYKSSMEI--------FANPIDTFSLIRHMQSNWLMWLLYLETPVGQEELFFV---- 122
                |..:||....||        ..|||:.|.||:....:|    ..:|:.:...:...|
 Worm    55 ----KLSEEYSKKNEISIENGLKDITNPINAFLLIKRKIFDW----KEIESKMNANKAGNVVSSI 111

  Fly   123 --DSRMPLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGVQYNSSLKPIDCLAIGLHLMNN 185
              ||.....|...|...||.|:.::|.||::.:.|:|.|.:...|.|.:....||..|.....|.
 Worm   112 TDDSYGVRYPTADDLSGAAIGLLRLQDTYRLDTKDLADGKIYADQGNYTFSAKDCFEIARAAYNE 176

  Fly   186 SRWYAAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQVALKLS 250
            ..:|....|:.   ||..:...:.:..:    ::.|:...|.....||.|.:.||:..:...|::
 Worm   177 HDFYHTVMWME---EAQRRLGDEVEPTV----EVEDILEYLAFALYKQNNLKHALKLTEELYKMN 234

  Fly   251 PHDPEI------YEEYRILEKRDLTLSD----IEPIEQDKDNS----HERLVLPPCCSGRCQVP- 300
            |..|..      ||:  :||:..:..||    :.||:..:.:|    .||.:....|  |.:||
 Worm   235 PTHPRAKGNVKWYED--LLEQEGVRRSDMRKNLPPIQNRRPDSVLGNTERTMYEALC--RNEVPV 295

  Fly   301 --RNLSNLYCVYNHVTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATT 363
              :::|.|||.|.. ..|||..||||.||...:|..||..|:||..|...|:..:|..:  :..|
 Worm   296 SQKDISRLYCYYKR-DRPFLVYAPIKVEIKRFNPLAVLFKDVISDDEVAAIQELAKPKL--ARAT 357

  Fly   364 DPDASDDETQVDTYRTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETH 428
            ..|:...:....|||.|||.|......|..:.:.:|:|..|.|:|.:.|..|:.|||:||.::.|
 Worm   358 VHDSVTGKLVTATYRISKSAWLKEWEGDVVETVNKRIGYMTNLEMETAEELQIANYGIGGHYDPH 422

  Fly   429 LDMLLSEKNR-FN--GTSDRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGND 490
            .|....|::: |.  ||.:||||.|||:::...||||.|.....|:.|....|||||||..:|:.
 Worm   423 FDHAKKEESKSFESLGTGNRIATVLFYMSQPSHGGGTVFTEAKSTILPTKNDALFWYNLYKQGDG 487

  Fly   491 HMGSLHTGCPVIVGSKWVMSKWINDMGQEFTRPCVESSLSSNEVLSAERLI 541
            :..:.|..|||:||.|||.:|||::.|.||.|||   .|.|::.   ||.:
 Worm   488 NPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRPC---GLKSSDY---ERFV 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	33/141 (23%)
		TPR repeat	175..200	CDD:276809	5/24 (21%)
		TPR_16	176..254	CDD:290168	15/77 (19%)
		TPR repeat	219..249	CDD:276809	7/29 (24%)
		TPR_2	220..253	CDD:285020	9/32 (28%)
		P4Hc	342..513	CDD:214780	64/173 (37%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:285528	33/141 (23%)
		P4Hc	338..511	CDD:214780	65/174 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4458
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.770