DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and P4ha1

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	166/526 - (31%)
Similarity:	257/526 - (48%)	Gaps:	68/526 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTD-------YDREKNLAEDPIKHFRI 90
            ||..|:.||..|..|:..|:.:..|.:.:::.::.:.|..|       .|.| .....|:..|::
  Rat    24 SIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPE-GFVGHPVNAFKL 87

  Fly    91 TRRLHSDYVNWVWFMEEQPWGTLVKDI-------IAIAPE-MPTLKDVEEAIRGLRLIQWTYSLP 147
            .:||:::     |...|   ..::||:       :.|..: .|..:|...|.:.|..:|.||:|.
  Rat    88 MKRLNTE-----WSELE---NLILKDMSDGFISNLTIQRQYFPNDEDQVGAAKALFRLQDTYNLD 144

  Fly   148 TAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADE--------EIE 204
            |..::||.|..:.|.:.|....|..:.:......|:...:.|:...|...|..|        .::
  Rat   145 TNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLEEGEMSTVDKVSVLD 209

  Fly   205 Y----IYSQ--LGMPLV---DFYELFVEIQDELGS----RYLAMSELQLAIKNWPEKVSLQRALS 256
            |    :|.|  |...|:   ...||..|.|...|:    .|: ||:.:.|.|:.....|.|:...
  Rat   210 YLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYI-MSKEKDANKSASGDQSDQKTTP 273

  Fly   257 RLKMNIRIGKEPAEKKNKSKRVYKKCCSSE-----CRPTAKLYCLYK--TTSSYFLRLAPLKMEL 314
            : |..|.:...|..:|      |:..|..|     .|...:|:|.|.  ..:..|: |||.|.|.
  Rat   274 K-KKGIAVDYLPERQK------YEMLCRGEGIKMTPRRQKRLFCRYHDGNRNPKFI-LAPAKQED 330

  Fly   315 LSLDPYMVLFHDVVSDKDIVSIRNLTKGKLAR-TVTVSKDGNYTEDPDRTTKGTWLV-ENNALIQ 377
            ....|.::.|||::||.:|..:::|.|.:|:| ||...:.|..|....|.:|..||. ..:.::.
  Rat   331 EWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYEDPVVS 395

  Fly   378 RLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELDNF-----SDRIATAVFYLSDV 437
            |::...||:|..|:..|:..||.|||:||.|..||||....|.|.|     .:||||.:||:|||
  Rat   396 RINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAFRELGTGNRIATWLFYMSDV 460

  Fly   438 PQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFR 502
            ..||||:||::|.||:||||:|:.||||...|:||..|.|:|||.:||::||..||::||.|.||
  Rat   461 SAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFR 525

  Fly   503 RPCLTS 508
            |||..|
  Rat   526 RPCTLS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/137 (24%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	76/171 (44%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	20/95 (21%)
		TPR	205..238		7/32 (22%)
		P4Hc	345..518	CDD:214780	77/172 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920