DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and p4ha3

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_021322008.1	Gene:	p4ha3 / 563281	ZFINID:	ZDB-GENE-041010-4	Length:	616	Species:	Danio rerio

Alignment Length:	540	Identity:	145/540 - (26%)
Similarity:	241/540 - (44%)	Gaps:	87/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILYLLVLV-KSHSK--PKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEM 71
            :||||.:. :|..:  ..:|..|.|:|.  ..||||  |.::.|    .:..|:..|...::..:
Zfish    10 VLYLLNMPDESFGEMFTSMLSVNQAVSA--ERKLID--HLIIYI----EHEAQRLEDIKRFFSRV 66

  Fly    72 TD-----YDREKNLAEDPIKHFRITRRLHSDYVNWVWFME-EQPWGTLVKDIIAIAPEMPTLKDV 130
            |.     |:...:...:||..|::.:||.|:::|.|...| |:....|.:|...:...:|.|:|:
Zfish    67 TSLHDGIYNEPSDPIANPIAAFKLVKRLKSEWLNVVHSTEAEENIKVLREDYRRMESSLPKLEDL 131

  Fly   131 EEAIRGLRLIQWTYSLPTAEMAKGVLQDIHH---------NTSLDGMQCITIARHMVNYKDFIRA 186
            ..|..||..:|..|:|....:.:|..|.|..         :..|.|..|..:.:...:.:|:..:
Zfish   132 RGAAHGLMRLQDVYNLHVESLVRGHFQQISDPVDFYKLSVSDMLSGDDCFLVGKVAYDLEDYYHS 196

  Fly   187 KEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSL 251
            ..|....::::...|     :|.         |....::|.|.  :||.|..:..  |....:||
Zfish   197 VLWFEEAVRLFRGTE-----WSP---------ENEGTLEDALD--HLAFSHFKTG--NISHALSL 243

  Fly   252 QRAL-------SRLKMNIRIGKE------PAEKKN-----------KSKRVYKKCCSSE-CRP-- 289
            .|.|       .|:..|:...::      ||....           :::..|::.|.:: .:|
Zfish   244 SRELLLHDPMNRRVHFNVEKYEKLLNENLPATSSGLTLKRPDGIYLRTRNAYEQLCQTKGSQPKH 308

  Fly   290 --TAKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLARTVTVSK 352
              ...|:|.|.|..|..|.|.|::.|::||.||:||||..|:..:..:||......|.|:|..|.
Zfish   309 FENPSLFCDYFTNGSPALFLQPIRREIISLQPYVVLFHGFVTQAEAKNIRKYAMPGLRRSVVASG 373

  Fly   353 DGNYTEDPDRTTKGTWLVEN-NALIQRLSQLTQDMTNFDIHD--ADPFQVLNYGIGGFYGIHFDF 414
            ....|.: .|.:|..||.|: :.::.:|.|....:|..::..  |:..||:||||||.|..|||
Zfish   374 MNQATAE-YRISKSAWLKESAHEVVGKLDQRITLVTGLNVQPPYAEYLQVVNYGIGGHYEPHFD- 436

  Fly   415 LEDAELDN-------FSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGD 472
              .|..|:       ..:|:||.:.|||.|..||:|.|.....||...:.:||.|:||...|.|:
Zfish   437 --HATSDSSPLYRLKTGNRVATIMIYLSPVQAGGSTAFIYANFSVPVVQNAALFWWNLHKNGQGN 499

  Fly   473 NRTAHSACPTVVGSRWVMTK 492
            ..|.|:.||.:||::|.|.|
Zfish   500 VDTLHAGCPVIVGNKWGMFK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/128 (26%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	59/174 (34%)
p4ha3	XP_021322008.1	P4Ha_N	27..157	CDD:311993	36/137 (26%)
p4ha3	XP_021322008.1	P4Hc	350..519	CDD:214780	58/172 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850