DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15539 and zgc:152670

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001070123.2	Gene:	zgc:152670 / 557059	ZFINID:	ZDB-GENE-060929-954	Length:	490	Species:	Danio rerio

Alignment Length:	528	Identity:	153/528 - (28%)
Similarity:	244/528 - (46%)	Gaps:	102/528 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ILENNYAISIYDMSKLIDYEHYLLNILQKFANALQ---KRVDTLEYYLEMTDYDREKNLAE---D 83
            |.|..:..|:..:|:|.:.|..||:....:.:|.:   |::.:|...|::..:...::..|   |
Zfish    18 ITEQEFFSSVDQVSQLFNEEENLLDTFSLYIDAEEENLKKMKSLLLLLQLGSFSNPQSPEETMRD 82

  Fly    84 PIKHFRITRRLHSDYVNWVWFMEE---QPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYS 145
            |:..|::.:||..::||...|.::   |.:.||:...:     :|.|:|:..|..||..:|..|.
Zfish    83 PVAAFKLLKRLRHEWVNIAKFTQQSLYQEFQTLLDYSL-----IPELEDINSAALGLIGLQEIYK 142

  Fly   146 L-PTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADE----EIEY 205
            | |                            |.:..:..:.|.|...:||..||.|:    .:.:
Zfish   143 LYP----------------------------HNITKETPLSADEAYYIGLVAYEEDKFQHAFLWF 179

  Fly   206 IYSQ-----------------LGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQR 253
            ::|.                 |......|..|.|.|       |.....|.|...|  |::.:|.
Zfish   180 LHSLNRLTDFSSTTKNDLLRFLSSSAYQFGSLPVAI-------YFGQKLLNLDPSN--EEIKVQL 235

  Fly   254 ALSRLKMNIRIGK----EPAEKKNKSKRVYKKCCSSEC-RPTAK----LYCLYKT-TSSYFLRLA 308
            .|.||   ||:.:    :......:|...|:..|..|. ..|:|    |.|.|.| ..:..|..|
Zfish   236 GLYRL---IRLQRTSNPDIFTLNTQSNNSYEALCRGEVDERTSKRQRALSCRYSTGGGNPRLMYA 297

  Fly   309 PLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLARTVT---VSKDGNYTEDPDRTTKGTWLV 370
            |:|.|.|..:|.::.:|||:||.:|.:::::.:.:|.|:.|   |..|       .||::..:|
Zfish   298 PVKEEELWDEPKIIRYHDVISDTEIETLKDIARPELTRSQTGWGVISD-------IRTSQSVFL- 354

  Fly   371 ENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELDNFSDRIATAVFYLS 435
            |....:.|:||...|:|...:..|:...|.||||||.|..|||     ..|..::|.||.:.|:|
Zfish   355 EEVGTVARISQRIADITGLSVESAEKLHVQNYGIGGRYTPHFD-----TGDEVNERTATFLIYMS 414

  Fly   436 DVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQI 500
            ||..||||:|..:|::|.|:||||:.||||...|:.|.:|.|:.||.:||::||..|||:|..|.
Zfish   415 DVEVGGATVFTNVGVAVKPEKGSAVFWYNLHKNGELDLKTKHAGCPVLVGNKWVANKWIHEFGQE 479

  Fly   501 FRRPCLTS 508
            |||||..|
Zfish   480 FRRPCSLS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	32/132 (24%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	64/167 (38%)
zgc:152670	NP_001070123.2	P4Ha_N	26..150	CDD:285528	33/156 (21%)
zgc:152670	NP_001070123.2	P4Hc	318..474	CDD:214780	65/168 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920