DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and P4HTM

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	467	Identity:	99/467 - (21%)
Similarity:	157/467 - (33%)	Gaps:	155/467 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DVEEAIRGLRLIQWTYSLPTAEMAKGVLQD-----IHHNTSLDGMQCITIARHMVNYKDFIRAKE 188
            |.:..||.|.|....:.:|      |.|.|     |.|...:.|:|...|.
Human   130 DRDHFIRTLSLKPLLFEIP------GFLTDEECRLIIHLAQMKGLQRSQIL-------------- 174

  Fly   189 WLMVGLKMYEADEEIEYIYSQLGMPLVDFYELF------------VEIQDELGSRYL----AMSE 237
                      ..||.|...|.:.:..:|.:.|.            |..|..||:.:.    ::.|
Human   175 ----------PTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQE 229

  Fly   238 LQLAIKNWPE---KVSLQRALSRLKMNIRIGKEPAEKKNKSKRVYKKCCSSECRPTAKLY----- 294
            :..|||..|:   .:|||                 |..|...|.:.|...|....:::|.
Human   230 MYAAIKADPDGDGVLSLQ-----------------EFSNMDLRDFHKYMRSHKAESSELVRNSHH 277

  Fly   295 -CLYKTTSSY---------FLRLAPLKMELLSL-DPYMVL-------FHDVVSDKDIVSIRNLTK 341
             .||:...::         .|||..|..|::.| :|..|:       :|..|....:......:.
Human   278 TWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSH 342

  Fly   342 GKLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDADPFQV---LNYG 403
            .||     |:.:....|...|.....|.:.  ::::..:.:||         |.|..|   |..|
Human   343 TKL-----VANESVPFETSCRQVSPNWGLP--SILRPGTPMTQ---------AQPCTVGVPLGMG 391

  Fly   404 IGGFYGIHFDFLEDAELDNFS-----DRIATAVFYLSDVPQGGATIFP----------------- 446
            .|..:.|.....|..:|...|     ....|.:|||::|..||.|:||
Human   392 PGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDV 456

  Fly   447 ----------KLGLSVFPKKGSALLWYNLDHKGDG-----DNRTAHSACPTVVGSRWVMTKWIN- 495
                      |..|.|.|::|:|:.|||....|.|     |:.:.|..|....|::|:...|||
Human   457 DLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINV 521

  Fly   496 ----EREQIFRR 503
                .|:.:|::
Human   522 DPSRARQALFQQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	7/26 (27%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	44/204 (22%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	15/76 (20%)
		EFh	194..252	CDD:238008	14/74 (19%)
		P4Hc	246..519	CDD:214780	64/305 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149314
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740