Protein Alignment CG15539 and P4HA1

DIOPT Version :10

• Sequence 1: NP_001036776.1
• Gene: CG15539 / 43627
• FlyBaseID: FBgn0039782
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 172/560 - (30%)
• Similarity: 268/560 - (47%)
• Gaps: 91/560 - (16%)

  Fly    10 ILYLLV----LVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLE 70
            |.|:|:    |.:|.:.|     .:..||..|:.||..|..|:..|:.:..|.:.:::.::.:.|
Human     2 IWYILIIGILLPQSLAHP-----GFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAE 61

  Fly    71 MTD-------YDREKNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTL----VKDI------- 117
            ..|       .|.| .....|:..|::.:||:::            |..|    :||:
Human    62 KLDRLTSTATKDPE-GFVGHPVNAFKLMKRLNTE------------WSELENLVLKDMSDGFISN 113

  Fly   118 IAIAPE-MPTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYK 181
            :.|..: .|..:|...|.:.|..:|.||:|.|..::||.|..:.|.:.|....|..:.:......
Human   114 LTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEA 178

  Fly   182 DFIRAKEWLMVGLKMYEADE-EIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNW 245
            |:...:.|:...|:  :.|| ||..|..   :.::|:....|..|.:|....|...:|   ::..
Human   179 DYYHTELWMEQALR--QLDEGEISTIDK---VSVLDYLSYAVYQQGDLDKALLLTKKL---LELD 235

  Fly   246 PEKVSLQRALSRLK-----------MNIRIGKEPAEKKNKSKR------------VYKKCCSSE- 286
            ||.   |||...||           :|.....:.:::|...|:            .|:..|..|
Human   236 PEH---QRANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEG 297

  Fly   287 ----CRPTAKLYCLYK--TTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLA 345
                .|...||:|.|.  ..:..|: |||.|.|.....|.::.|||::||.:|..:::|.|.:|:
Human   298 IKMTPRRQKKLFCRYHDGNRNPKFI-LAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLS 361

  Fly   346 R-TVTVSKDGNYTEDPDRTTKGTWLV-ENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFY 408
            | ||...:.|..|....|.:|..||. ..|.::.|::...||:|..|:..|:..||.|||:||.|
Human   362 RATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQY 426

  Fly   409 GIHFDFLEDAELDNFSD-----RIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHK 468
            ..||||....|.|.|.:     ||||.:||:|||..||||:||::|.||:||||:|:.||||...
Human   427 EPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFAS 491

  Fly   469 GDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPCLTS 508
            |:||..|.|:|||.:||::||..||::||.|.|||||..|
Human   492 GEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLS 531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..158	CDD:462433	34/143 (24%)
		P4Hc	329..494	CDD:214780	77/171 (45%)
P4HA1	NP_000908.2	P4Ha_N	24..155	CDD:462433	34/143 (24%)
		TPR	205..238		7/35 (20%)
		P4Hc	345..518	CDD:214780	78/172 (45%)