DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and p4ha2

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	563	Identity:	167/563 - (29%)
Similarity:	263/563 - (46%)	Gaps:	86/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTD 73
            |.|..|:...|.|.|...|  ...||..|:.||..|..|:..|:::..|.:::::|:..:....|
Zfish     3 AFLVFLLSTLSFSSPTRAE--IFTSIGQMTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLD 65

  Fly    74 -------YDREKNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVE 131
                   .|.|..||. |:..:::.:||::::......:.:.|....:.::.......|..:|.:
Zfish    66 KLTRTSTSDPEGFLAH-PVNAYKLMKRLNTEWSELESLVLQDPSDGFISNMSVHRQYFPDEEDEK 129

  Fly   132 EAIRGLRLIQWTYSLPTAEMAKGVL------QDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWL 190
            .|.:.|..:|.||.|.....:||.|      ..:.:|..|....|..:.:...|..|:..:..|:
Zfish   130 GAAKALLRLQDTYKLDAESFSKGKLPGQRQHSGVRYNALLTVDDCFDMGKMAYNDNDYYHSVLWM 194

  Fly   191 MVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQRAL 255
            ...|:..::.||.:       .|..|..:            ||:.|..|:.  :.|..:.|.|.|
Zfish   195 QQSLRQMDSGEEAK-------TPKADVLD------------YLSYSVYQMG--DLPRAIELTRRL 238

  Fly   256 -------SRLKMNIR-----IGK----------EPAEKKN-------------KSKRVYKKCCSS 285
                   .|...|:|     :.|          |||:::.             ..:..|:..|..
Zfish   239 LAIDPSHQRAGGNLRYFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRG 303

  Fly   286 E-----CRPTAKLYCLYKT-TSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKL 344
            |     .:..::|:|.|:. ..:..|.|.|:|.|.....|::|.|.:.:||::|..|:.:...||
Zfish   304 EGVKMTTKRQSRLFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKL 368

  Fly   345 AR-TVTVSKDGNYTEDPDRTTKGTWLV-ENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGF 407
            || ||...|.|..|....|.:|..||. |::.:|.|::|..:|:|...:..|:..||.|||:||.
Zfish   369 ARATVRDPKTGVLTVAHYRVSKSAWLEGEDDPVIARVNQRIEDITGLTVDTAELLQVANYGVGGQ 433

  Fly   408 YGIHFDFLEDAELDNF-----SDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDH 467
            |..||||....|.|.|     .:|:||.:.|:|||..||||:||..|.||:|:||:|:.||||..
Zfish   434 YEPHFDFSRKDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFR 498

  Fly   468 KGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPC-LTSI 509
            .|:||.||.|:|||.:|||:||..|||:||.|.||||| ||.:
Zfish   499 SGEGDYRTRHAACPVLVGSKWVSNKWIHERGQEFRRPCGLTEV 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	29/129 (22%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	78/171 (46%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	29/129 (22%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	79/172 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920