DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and P4ha3

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	XP_038938408.1	Gene:	P4ha3 / 361612	RGDID:	735150	Length:	549	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	131/520 - (25%)
Similarity:	220/520 - (42%)	Gaps:	105/520 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AILYLLVL-VKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMT 72
            |:|.||.| |...:.....|:.:: ::..:::.:..|..||..|:::....:.|:..|..:
  Rat     9 ALLVLLELGVGDPAAAAGREDTFS-ALTSVARALAPERRLLGTLRRYLRGEEARLRDLTRF---- 68

  Fly    73 DYDREKNLAED-------PIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKD-IIAIAPEMPTLKD 129
             ||:..:|.||       |:..|.:.:||.||:.|.|..:|.......:|| ...:..::|..:|
  Rat    69 -YDKVLSLHEDLKIPVVNPLLAFTLIKRLQSDWRNVVHSLEATENIRALKDGYEKVEQDLPAFED 132

  Fly   130 VEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNT-----------SLDGMQCITIARHMVNYKDF 183
            :|.|.|.|..:|..|.|....:|:||.|.:..::           ||....|..:.:...:..|:
  Rat   133 LEGAARALMRLQDVYMLNVKGLAQGVFQRVTGSSITDLYSPRQLFSLTADDCFQVGKVAYDTGDY 197

  Fly   184 IRAKEWLMVGLKMY-------EADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLA 241
            ..|..||...:.::       :.::|                   ..::|.|.  |||.:..|:.
  Rat   198 YHAIPWLEEAVSLFRRSYGEWKTEDE-------------------ASLEDALD--YLAFACYQVG 241

  Fly   242 IKNWPEKVSLQRALSR----------------LKM--------NIRIGKEPAEKKN----KSKRV 278
                  .||...:|||                ||.        ::...:...::.|    :::..
  Rat   242 ------NVSCALSLSREFLVYSPDNKRMARNVLKYERLLAENGHLMAAETAIQRPNVPHLQTRDT 300

  Fly   279 YKKCCSS-ECRPT----AKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRN 338
            |:..|.: ..:||    ..|||.|:|.||.:|.|.|.:.|::.|.|.:.|:||.|||::...||.
  Rat   301 YEGLCQTLGSQPTHYQIPSLYCSYETNSSPYLLLQPARKEVIHLRPLVALYHDFVSDEEAQKIRE 365

  Fly   339 LTKGKLARTVTVSKDGNYTEDPDRTTKGTWLVEN-NALIQRLSQLTQDMTNFDIHD--ADPFQVL 400
            |.:..|.|:|..|.: ...:...|.:|..||.:. :.::..|.:....:|..||..  |:..||:
  Rat   366 LAEPWLQRSVVASGE-KQLQVEYRISKSAWLKDTVDPVLVTLDRRIAALTGLDIQPPYAEYLQVV 429

  Fly   401 NYGIGGFYGIHFDFLEDAELDNF----SDRIATAVFYLSDVPQGGATIFPKLGLSV----FPKKG 457
            ||||||.|..|||.........:    .:|:||.:.|||.|..||||.|.....||    :|..|
  Rat   430 NYGIGGHYEPHFDHATSPSSPLYKMKSGNRVATLMIYLSSVEAGGATAFIYGNFSVPVVKWPTSG 494

Fly 458 457
Rat 495 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/130 (25%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	46/140 (33%)
P4ha3	XP_038938408.1	P4Ha_N	34..108	CDD:400573	19/78 (24%)
P4ha3	XP_038938408.1	P4Hc	356..>478	CDD:214780	41/122 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750