DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15539 and P4ha2

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	164/551 - (29%)
Similarity:	259/551 - (47%)	Gaps:	74/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LYLLVLVKS-HSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDY 74
            |.:|||:.| ......::..:..||..|:.||..|..|:..|:::..|.:.::..::.:....:.
  Rat     3 LQVLVLLMSWFGVLSWVQAEFFTSIGHMTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEA 67

  Fly    75 DREKNLAE------DPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEA 133
            ...|:.|:      .|:..:::.:||::|:......:.:......|.::.......||.:|...|
  Rat    68 LTSKSAADPEGYLAHPVNAYKLVKRLNTDWPALGDLVLQDAAAGFVANLSVQRQFFPTDEDESGA 132

  Fly   134 IRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYE 198
            .|.|..:|.||.|....:::|.|....:...|....|..:.|...|..|:.....|:...||..:
  Rat   133 ARALMRLQDTYKLDPDMISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLD 197

  Fly   199 ADEE-----------IEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQ 252
            |.||           :.|...|||    |.:...     ||..|.|::..            |.:
  Rat   198 AGEEATVTKSLVLDYLSYAVFQLG----DLHRAV-----ELTRRLLSLDP------------SHE 241

  Fly   253 RALSRLKMNIRIGKEP-------------AEKKNKSKR---------VYKKCCSSE-----CRPT 290
            ||...|:...|:.:|.             |.::|..:|         ||:..|..|     .|..
  Rat   242 RAGGNLRYFERLLEEERGKSLSNQTDAGLASQENLYERPVDYLPERDVYESLCRGEGIKMTPRRQ 306

  Fly   291 AKLYCLYKTTSSY-FLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLAR-TVTVSKD 353
            .:|:|.|...:.. .|.:||.|.|.....|::|.::||:||::|..|:.:.|.|||| ||...|.
  Rat   307 KRLFCRYHHGNRVPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKT 371

  Fly   354 GNYTEDPDRTTKGTWLVE-NNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLED 417
            |..|....|.:|.:||.| ::.::.|:::..|.:|...:..|:..||.|||:||.|..||||...
  Rat   372 GVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRS 436

  Fly   418 AELDNF-----SDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAH 477
            .|.|.|     .:|:||.:.|:|||..||||:||.||.:::||||:|:.||||...|:||.||.|
  Rat   437 DERDAFKRLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRH 501

  Fly   478 SACPTVVGSRWVMTKWINEREQIFRRPCLTS 508
            :|||.:||.:||..||.:||.|.|.|||.|:
  Rat   502 AACPVLVGCKWVSNKWFHERGQEFLRPCGTT 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	27/128 (21%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	76/171 (44%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	14/76 (18%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	77/172 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920