DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and PH4alphaNE3

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_651814.1	Gene:	PH4alphaNE3 / 326114	FlyBaseID:	FBgn0051017	Length:	481	Species:	Drosophila melanogaster

Alignment Length:	474	Identity:	150/474 - (31%)
Similarity:	237/474 - (50%)	Gaps:	43/474 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KLIDYEHYLLNILQKF---ANALQKRVDTLEYYLEMTDYDREKNLAEDPIKHFRITRRLHSDYVN 100
            :|||   .|:|..:|.   |:.|::....|...|.... .||:....:|:..|.:.|.::.|:..
  Fly    33 ELID---NLMNYAEKIDEKASQLKRLAQELRQPLHSAK-GREEEYLGNPLHSFPLIRHMYQDWRY 93

  Fly   101 WVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSL 165
            ...||::......::.:....||:|...|.|||...:..|..||.:...:||.|::.::..|::|
  Fly    94 LEEFMKKPVGEEEIQFLRRKLPELPWQVDTEEASVSIFRIAETYGMMPWDMANGLIDNVRFNSTL 158

  Fly   166 DGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGS 230
            ..:.|..:|:....:..|.:|.:|:.:.....:  ||...:|..|||...|...|......||..
  Fly   159 PALDCFEVAKMYFKWGYFKQALQWITISKARMK--EEYSGVYEVLGMNRQDVALLQARCLVELDR 221

  Fly   231 RYLAMSELQLAIKNWPE----KVSLQRALSRLKMNIRIGKEPAEKKNKSKRV---YKKCCSSECR 288
            |    .|....:.:.|:    .:||   |.:.|.|      |.|..:.|.::   ||:.|.|...
  Fly   222 R----DEAHEVLLDQPDLADNSISL---LDQFKAN------PYEAIDSSPKLGEGYKRLCRSSFS 273

  Fly   289 PT-AKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLARTVTVSK 352
            |. :||:|.|.:|:|.||.|||||||.:||:|::|::||::.||||..:..|.:..|..|.....
  Fly   274 PNPSKLHCRYNSTTSAFLILAPLKMEEISLEPHIVVYHDILPDKDIQQLITLAEPLLKPTEMFDD 338

  Fly   353 DGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLE- 416
            :.|......||..|      ..|:..|:|..:|:|...|...:|..::.||.|..|..::||.:
  Fly   339 NKNEARSSYRTPLG------GPLLDSLTQRMRDITGLQIRQGNPINIIKYGFGAPYTNYYDFFKK 397

  Fly   417 -DAELDNFSDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLD---HKGDGDNRTAH 477
             ::|...|.||:||.:|||:|.|.||||:||:|.:.|..::|..|.||||:   |  |.:..|.|
  Fly   398 RNSESKGFGDRMATFMFYLNDAPYGGATVFPRLNVKVPAERGKVLFWYNLNGDTH--DMEPTTMH 460

  Fly   478 SACPTVVGSRWVMTKWINE 496
            :|||...||:||||.||:|
  Fly   461 AACPVFHGSKWVMTAWIHE 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	31/119 (26%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	62/169 (37%)
PH4alphaNE3	NP_651814.1	P4Ha_N	25..149	CDD:285528	31/119 (26%)
PH4alphaNE3	NP_651814.1	P4Hc	316..478	CDD:214780	63/169 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461726
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900