DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15539 and CG31013

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_733394.3	Gene:	CG31013 / 326111	FlyBaseID:	FBgn0051013	Length:	534	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	183/532 - (34%)
Similarity:	291/532 - (54%)	Gaps:	49/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMT 72
            |.:|:...||..| :|  ||.::::|:..|..|::.|..|::.|:.:.|||:::::.:...|.:.
  Fly     9 LVMLFHSTLVLGH-RP--LEKSHSLSLVTMVPLLELEKKLIDNLENYTNALEQKLEIIRSQLLVI 70

  Fly    73 DYDREK------NLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGT-LVKDIIAIAPEMPTLKDV 130
            ..:.||      :...:|:..|.|.||||.|::||..:| |||.|. .:|...:...|:||.:|:
  Fly    71 RAENEKGRRNAISYLSNPLNGFSIIRRLHQDWINWRKYM-EQPVGIWQLKAFYSWKDELPTERDL 134

  Fly   131 EEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLM-VGL 194
            .:|..|:..||.||.|...:...|.:....:|.|:.....:::..::........|.:||. |..
  Fly   135 WDACEGIARIQSTYDLKVGDFINGNINGKQYNDSMSTADILSVGAYLFMKNRPSDAIQWLQEVPQ 199

  Fly   195 KMYEADEEIEYIYSQLGMPL--VDFYELFVE--IQDELGSRYLAMSELQLAIKNWPEKVSLQRAL 255
            ::.|     |.:.....:|:  ||...|..|  |:|:..|..|.:  |...:|..|....:.|..
  Fly   200 RLQE-----ELLIQPRHLPIKEVDALRLLAEAQIKDQNYSEALPL--LHNCLKLQPHDARVLRLW 257

  Fly   256 SRLKMNIRIGKEPAEKKNKSKRV-----YKKCCSSECRPTAKLYCLYKTTSSYFLRLAPLKMELL 315
            .:....|....:.:..:||.:.|     :|..|:.....:.:|:|.|..|::.||||||||.|.:
  Fly   258 KKTTDFIENQPDQSPTENKKRNVPIANAFKLSCNGPLESSTRLHCFYNFTTTPFLRLAPLKTEQI 322

  Fly   316 SLDPYMVLFHDVVSDKDIVSI-----RNLTKGKLARTVTVSKDGNYTEDPDRTTKGTWL-VENNA 374
            .||||:||:|:|:|.::|..:     :|:...|:.:...|.|     ::..||.||.|| .|:|.
  Fly   323 GLDPYVVLYHEVLSAREISMLIGKAAQNMKNTKIHKERAVPK-----KNRGRTAKGFWLKKESNE 382

  Fly   375 LIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELD----------NFSDRIAT 429
            |.:|:::...|||.||:.|::.|||:||||||.|.:|.|:.:.|..:          :..|||||
  Fly   383 LTKRITRRIMDMTGFDLADSEGFQVINYGIGGHYFLHMDYFDFASSNHTDTRSRYSIDLGDRIAT 447

  Fly   430 AVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWI 494
            .:|||:||.|||||:|..:|..|.|:.|:|:.|||||..|:||.||.|:|||.:|||:||||:||
  Fly   448 VLFYLTDVEQGGATVFGDVGYYVSPQAGTAIFWYNLDTDGNGDPRTRHAACPVIVGSKWVMTEWI 512

  Fly   495 NEREQIFRRPCL 506
            .|:.|||.||||
  Fly   513 REKRQIFIRPCL 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	40/129 (31%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	77/180 (43%)
CG31013	NP_733394.3	P4Ha_N	31..160	CDD:285528	40/129 (31%)
		TPR_11	178..248	CDD:290150	17/76 (22%)
		TPR repeat	211..246	CDD:276809	10/36 (28%)
		P4Hc	336..513	CDD:214780	78/181 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461735
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	10	9.900