DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and P4HA3

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001275677.1	Gene:	P4HA3 / 283208	HGNCID:	30135	Length:	604	Species:	Homo sapiens

Alignment Length:	499	Identity:	126/499 - (25%)
Similarity:	209/499 - (41%)	Gaps:	77/499 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTD 73
            |:|.:|.|.....:......:...::..:::.:..|..||.:|:::....:.|:..|..:
Human     9 ALLAVLALGTGDPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRGEEARLRDLTRF----- 68

  Fly    74 YDREKNLAED-------PIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKD-IIAIAPEMPTLKDV 130
            ||:..:|.||       |:..|.:.:||.||:.|.|..:|.......:|| ...:..::|..:|:
Human    69 YDKVLSLHEDSTTPVANPLLAFTLIKRLQSDWRNVVHSLEASENIRALKDGYEKVEQDLPAFEDL 133

  Fly   131 EEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNT-----------SLDGMQCITIARHMVNYKDFI 184
            |.|.|.|..:|..|.|....:|:||.|.:..:.           ||.|..|..:.:...:..|:.
Human   134 EGAARALMRLQDVYMLNVKGLARGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGKVAYDMGDYY 198

  Fly   185 RAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKV 249
            .|..||         :|.:.......|....:......:..|.|...|.....:..|:
Human   199 HAIPWL---------EEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCAL------- 247

  Fly   250 SLQRAL-------SRLKMNI-RIGKEPAEKKN----------------KSKRVYKKCCSS-ECRP 289
            ||.|..       .|:..|: :..:..||..|                :::..|:..|.: ..:|
Human   248 SLSREFLLYSPDNKRMARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQP 312

  Fly   290 T----AKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLARTVTV 350
            |    ..|||.|:|.|:.:|.|.|::.|::.|:||:.|:||.|||.:...||.|.:..|.|:|..
Human   313 TLYQIPSLYCSYETNSNAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVA 377

  Fly   351 SKDGNYTEDPDRTTKGTWLVEN-NALIQRLSQLTQDMTNFDIHD--ADPFQVLNYGIGGFYGIHF 412
            |.: ...:...|.:|..||.:. :..:..|:.....:|..|:..  |:..||:||||||.|..||
Human   378 SGE-KQLQVEYRISKSAWLKDTVDPKLVTLNHRIAALTGLDVRPPYAEYLQVVNYGIGGHYEPHF 441

  Fly   413 DFLEDAELDNF----SDRIATAVFYLSDVPQGGATIFPKLGLSV 452
            |.........:    .:|:||.:.|||.|..||||.|....|||
Human   442 DHATSPSSPLYRMKSGNRVATFMIYLSSVEAGGATAFIYANLSV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/130 (25%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	44/131 (34%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	29/105 (28%)
		TPR_12	186..252	CDD:290160	12/81 (15%)
		P4Hc	356..>478	CDD:214780	40/122 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750