DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15539 and P4ha1

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001303300.1	Gene:	P4ha1 / 18451	MGIID:	97463	Length:	534	Species:	Mus musculus

Alignment Length:	554	Identity:	170/554 - (30%)
Similarity:	270/554 - (48%)	Gaps:	73/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LISLAILYLLVLVKSHSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYL 69
            :|.:.::..::|.:|.:.|     .:..||..|:.||..|..|:..|:.:..|.:.:::.::.:.
Mouse     1 MIWVVLMMAILLPQSLAHP-----GFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWA 60

  Fly    70 EMTD-------YDREKNLAEDPIKHFRITRRLHSDYVNWVWFMEEQPWGTLVKDI-------IAI 120
            |..|       .|.| .....|:..|::.:||:::     |...|   ..::||:       :.|
Mouse    61 EKLDRLTSTATKDPE-GFVGHPVNAFKLMKRLNTE-----WSELE---NLILKDMSDGFISNLTI 116

  Fly   121 APE-MPTLKDVEEAIRGLRLIQWTYSLPTAEMAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFI 184
            ..: .|..:|...|.:.|..:|.||:|.|..::||.|..:.|.:.|....|..:.:......|:.
Mouse   117 QRQYFPNDEDQVGAAKALFRLQDTYNLDTNTISKGNLPGVQHKSFLTAEDCFELGKVAYTEADYY 181

  Fly   185 RAKEWLMVGLKMYEADE--------EIEY----IYSQ--LGMPLV---DFYELFVEIQDELGS-- 230
            ..:.|:...|...|..|        .::|    :|.|  |...|:   ...||..|.|...|:
Mouse   182 HTELWMEQALTQLEEGELSTVDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLV 246

  Fly   231 --RYLAMSELQLAIKNWPEKVSLQRALSRLKMNIRIGKEPAEKKNKSKRVYKKCCSSE-----CR 288
              .|: ||:.:.|.|:.....|.|:...: |..|.:...|..:|      |:..|..|     .|
Mouse   247 YFEYI-MSKEKDANKSASGDQSDQKTAPK-KKGIAVDYLPERQK------YEMLCRGEGIKMTPR 303

  Fly   289 PTAKLYCLYK--TTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTKGKLAR-TVTV 350
            ...:|:|.|.  ..:..|: |||.|.|.....|.::.|||::||.:|..:::|.|.:|:| ||..
Mouse   304 RQKRLFCRYHDGNRNPKFI-LAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHD 367

  Fly   351 SKDGNYTEDPDRTTKGTWLV-ENNALIQRLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDF 414
            .:.|..|....|.:|..||. ..:.::.|::...||:|..|:..|:..||.|||:||.|..||||
Mouse   368 PETGKLTTAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDF 432

  Fly   415 LEDAELDNF-----SDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNR 474
            ....|.|.|     .:||||.:||:|||..||||:||::|.||:||||:|:.||||...|:||..
Mouse   433 ARKDEPDAFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYS 497

  Fly   475 TAHSACPTVVGSRWVMTKWINEREQIFRRPCLTS 508
            |.|:|||.:||::||..||::||.|.|||||..|
Mouse   498 TRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLS 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/137 (24%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	76/171 (44%)
P4ha1	NP_001303300.1	P4Ha_N	24..153	CDD:285528	33/137 (24%)
		TPR	205..238		7/32 (22%)
		P4Hc	345..518	CDD:214780	77/172 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920