DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15539 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	526	Identity:	149/526 - (28%)
Similarity:	256/526 - (48%)	Gaps:	56/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTD-------YDREKNLAEDPI 85
            |::..|...|:.|:..|..|:..|:::....:.|::.::.:.:..|       .|.|..|.. |:
Zfish    19 NDFFTSTGQMTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGFLGH-PV 82

  Fly    86 KHFRITRRLHSDYVNWVWFMEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGLRLIQWTYSLPTAE 150
            ..|::.:||:|::.:....:.:......:.::.......||.:|...|.:.|..:|.||.|....
Zfish    83 NAFKLMKRLNSEWSDLENLVLKDTTNGFISNLTVQRQYFPTDEDQTGAAKALLRLQDTYQLSANA 147

  Fly   151 MAKGVLQDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEE--IEYIYSQLGMP 213
            ::.|.|..:.|.:.:....|..:.:...:..|:...:.|:...|...:..||  |:.:      .
Zfish   148 ISSGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDEGEESPIDKV------T 206

  Fly   214 LVDFYELFVEIQDELG------SRYLAMS-----------------ELQLAIKNWPEKVSLQRAL 255
            ::|:....:..|.||.      .|.|.:.                 |.|...:|..::...:|.|
Zfish   207 VMDYLSYAIYQQGELDRALELTKRMLKLDPNHHRANGNLKYFEFQLEKQRKAENEKKEEDQKRVL 271

  Fly   256 SRLKMNIRIGKEPAEKKNKSKRVYKKCCSSE-----CRPTAKLYCLYKTTS-SYFLRLAPLKMEL 314
            .:.....:..|:|..::.|    |::.|..|     .|..::|:|.|...: :..|.|||:|.|.
Zfish   272 DKRDAQRKRSKDPLPERKK----YERLCRGEGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQED 332

  Fly   315 LSLDPYMVLFHDVVSDKDIVSIRNLTKGKLAR-TVTVSKDGNYTEDPDRTTKGTWLV-ENNALIQ 377
            ....|.:|.:|:::||.:|.:::.:.|.:|.| |::....|.....|.|.:|..||. ..::.|:
Zfish   333 EWDRPRIVRYHEIISDSEIETVKEMAKPRLRRATISNPITGVLETAPYRISKSAWLSGYEHSTIE 397

  Fly   378 RLSQLTQDMTNFDIHDADPFQVLNYGIGGFYGIHFDFLEDAELDNFSD-----RIATAVFYLSDV 437
            |::|..:|:|..::..|:..||.|||:||.|..||||....|.|.|.:     ||||.:||:|||
Zfish   398 RINQRIEDVTGLEMDTAEELQVANYGVGGQYEPHFDFGRKDEPDAFKELGTGNRIATWLFYMSDV 462

  Fly   438 PQGGATIFPKLGLSVFPKKGSALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFR 502
            ..||||:|..:|.:|:||||:|:.||||...|:||..|.|:|||.:||::||..|||:||.|.||
Zfish   463 SAGGATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFR 527

  Fly   503 RPCLTS 508
            |||..|
Zfish   528 RPCALS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	26/129 (20%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	72/171 (42%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	26/129 (20%)
		TPR repeat	164..199	CDD:276809	4/34 (12%)
		TPR_16	168..238	CDD:290168	12/75 (16%)
		TPR repeat	204..234	CDD:276809	6/35 (17%)
		P4Hc	347..520	CDD:214780	73/172 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920