DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31371 and P4HA2

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_001136071.1	Gene:	P4HA2 / 8974	HGNCID:	8547	Length:	535	Species:	Homo sapiens

Alignment Length:	523	Identity:	134/523 - (25%)
Similarity:	234/523 - (44%)	Gaps:	71/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LW---LLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEE 69
            ||   ||..:..|.|...|.|......:..|:..|.:|:..|::||...|.:|.:|:...:.:|.
Human     3 LWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEA 67

  Fly    70 IHSQ-VDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEES 133
            :.|: ....|.|:.:|:|.:.::||..:.||.||..........|...||.::...|::||...:
Human    68 LTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGA 132

  Fly   134 LNHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLP 194
            ...|:.||..|.||..::|.|.:.|.|..:.:|..||..:.|    :.|:.....|:|..|::|.
Human   133 AKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLD 197

  Fly   195 SASE-NSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIEKA 258
            :..| .:|:||         :|:......::.|:|.|||.....||.|.|.::......|..|:
Human   198 AGEEATTTKSQ---------VLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQ- 252

  Fly   259 MAKKELPKGRGQKSKA---------KKQISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQ 308
            :.::|..|....:::|         ::.:....|:.:.|.:|||      .::|.....|::|
Human   253 LLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHH-- 315

  Fly   309 LDGSSPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEE------EDTK-GV----SY 362
             ...:|.||:.|.:.|.....|:||.::||::.:|...:.::...:      .|.| ||    ||
Human   316 -GNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASY 379

  Fly   363 QSLKLSKLAQKK---LGRISR----LLGL-----EILELDPW--TGRRHGHEHITKLEHSSELKH 413
            :..|.|.|.:..   :.|::|    :.||     |:|::..:  .|:...|...::.:.....||
Human   380 RVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKH 444

  Fly   414 ------VARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQAICPV 472
                  ||..:..:.....|||.|||.|..|:...:|:.:.|......|   |.|||:..|.|||
Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSG---EGDYRTRHAACPV 506

  Fly   473 LLG 475
            |:|
Human   507 LVG 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	35/126 (28%)
P4HA2	NP_001136071.1	P4Ha_N	26..155	CDD:311993	35/128 (27%)
		TPR	207..240		12/41 (29%)
		P4Hc	346..519	CDD:214780	43/167 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020