Protein Alignment CG31371 and P4HA2

DIOPT Version :10

• Sequence 1: NP_733375.2
• Gene: CG31371 / 43626
• FlyBaseID: FBgn0051371
• Length: 507
• Species: Drosophila melanogaster
• Sequence 2: NP_004190.1
• Gene: P4HA2 / 8974
• HGNCID: 8547
• Length: 535
• Species: Homo sapiens
• Alignment Length: 523
• Identity: 134/523 - (25%)
• Similarity: 234/523 - (44%)
• Gaps: 71/523 - (13%)

  Fly     8 LW---LLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEE 69
            ||   ||..:..|.|...|.|......:..|:..|.:|:..|::||...|.:|.:|:...:.:|.
Human     3 LWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEA 67

  Fly    70 IHSQ-VDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEES 133
            :.|: ....|.|:.:|:|.:.::||..:.||.||..........|...||.::...|::||...:
Human    68 LTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGA 132

  Fly   134 LNHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLP 194
            ...|:.||..|.||..::|.|.:.|.|..:.:|..||..:.|    :.|:.....|:|..|::|.
Human   133 AKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLD 197

  Fly   195 SASE-NSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIEKA 258
            :..| .:|:||         :|:......::.|:|.|||.....||.|.|.::......|..|:
Human   198 AGEEATTTKSQ---------VLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQ- 252

  Fly   259 MAKKELPKGRGQKSKA---------KKQISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQ 308
            :.::|..|....:::|         ::.:....|:.:.|.:|||      .::|.....|::|
Human   253 LLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHH-- 315

  Fly   309 LDGSSPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDEE------EDTK-GV----SY 362
             ...:|.||:.|.:.|.....|:||.::||::.:|...:.::...:      .|.| ||    ||
Human   316 -GNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASY 379

  Fly   363 QSLKLSKLAQKK---LGRISR----LLGL-----EILELDPW--TGRRHGHEHITKLEHSSELKH 413
            :..|.|.|.:..   :.|::|    :.||     |:|::..:  .|:...|...::.:.....||
Human   380 RVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKH 444

  Fly   414 ------VARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQAICPV 472
                  ||..:..:.....|||.|||.|..|:...:|:.:.|......|   |.|||:..|.|||
Human   445 LGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSG---EGDYRTRHAACPV 506

  Fly   473 LLG 475
            |:|
Human   507 LVG 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..158	CDD:462433	35/128 (27%)
P4HA2	NP_004190.1	P4Ha_N	26..157	CDD:462433	35/130 (27%)
		BamD	159..>272	CDD:443281	29/122 (24%)
		TPR	207..240		12/41 (29%)
		P4Hc	346..519	CDD:214780	43/167 (26%)