DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31371 and P4ha1

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_742059.2	Gene:	P4ha1 / 64475	RGDID:	621000	Length:	534	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	127/527 - (24%)
Similarity:	232/527 - (44%)	Gaps:	77/527 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VLW--LLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIEE 69
            ::|  |:...||.:..|...|.....|:..|:..|..|:..|:|||:..|.:||:|::....::.
  Rat     1 MIWGVLMMGILLPQCSAHPGFFTSIGQMTDLIHNEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDR 65

  Fly    70 IHS-QVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEES 133
            :.| .....|.::|:|:|.|.::||..:.|..||......:...|...|:.::...|::||...:
  Rat    66 LTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLILKDMSDGFISNLTIQRQYFPNDEDQVGA 130

  Fly   134 LNHLLHLQSVYELDSNSLSLGVVNGFKLGSSMSWGDCLEVAR----KSDFPVARFWLESALEKLP 194
            ...|..||..|.||:|::|.|.:.|.|..|.::..||.|:.:    ::|:.....|:|.||.:|.
  Rat   131 AKALFRLQDTYNLDTNTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADYYHTELWMEQALMQLE 195

  Fly   195 SASENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQGIQKAKRKIEKAM 259
            ....::.:        :|.:|:......|:.|:|.:||...::||.|.|.:|.........|..|
  Rat   196 EGEMSTVD--------KVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLVYFEYIM 252

  Fly   260 AK-KELPKGRG-----QKSKAKKQ---ISKSTEQLLIEEICRG------AKQQVTTGSRFNHCQL 309
            :| |:..|...     ||:..||:   :....|:...|.:|||      .::|.....|::
  Rat   253 SKEKDANKSASGDQSDQKTTPKKKGIAVDYLPERQKYEMLCRGEGIKMTPRRQKRLFCRYH---- 313

  Fly   310 DGS-SPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDE------------EEDTKGVS 361
            ||: :|..:|.|::.|.....|.|:..||:::..|    ::::.:            :.:|..::
  Rat   314 DGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAE----IEIVKDLAKPRLSRATVHDPETGKLT 374

  Fly   362 YQSLKLSKLA----------QKKLGRISRLLGLEILELDPWTGRRHG-------HEHITKLEHSS 409
            ....::||.|          .:...||..|.||::...:......:|       |....:.:...
  Rat   375 TAQYRVSKSAWLSGYEDPVVSRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPD 439

  Fly   410 ELK------HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRSGQA 468
            ..:      .:|..:..:.....|||.|||::..:|...:|:.:.|...||.|   |.||.:..|
  Rat   440 AFRELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASG---EGDYSTRHA 501

  Fly   469 ICPVLLG 475
            .||||:|
  Rat   502 ACPVLVG 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	37/126 (29%)
P4ha1	NP_742059.2	P4Ha_N	25..112	CDD:400573	24/86 (28%)
		TPR	205..238		11/32 (34%)
		P4Hc	345..518	CDD:214780	34/171 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920