DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31371 and p4ha1a

DIOPT Version :9

Sequence 1:	NP_733375.2	Gene:	CG31371 / 43626	FlyBaseID:	FBgn0051371	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_009304776.1	Gene:	p4ha1a / 562774	ZFINID:	ZDB-GENE-040724-91	Length:	541	Species:	Danio rerio

Alignment Length:	530	Identity:	135/530 - (25%)
Similarity:	232/530 - (43%)	Gaps:	76/530 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VFSVLWLLQLFLLVESVAGANFARGEEQLQALLDTETQLIDGLRDYIERLERQLEEIRRETSAIE 68
            |.||...|.:.||..|.|.::|......:..||.||..|:..|:|||:..|.:||::::....::
Zfish     4 VRSVCCFLLISLLKSSSAHSDFFTSIGHMTDLLFTEKDLVTSLKDYIKAEESKLEQVKQWAEKLD 68

  Fly    69 EI-HSQVDSVEEYMGNPLNVFGILKRFESVWPGLEQKANATLEMVFGERLSDRQLTLPSEEDYEE 132
            .: .:.|...|.::|:|:|.|.::||..:.|..:|......:...|...|:.::...|::||...
Zfish    69 ALTATAVQDPEGFLGHPVNAFKLMKRLNTEWGEVEDLVLKDMSDGFISNLTIQRQYFPNDEDQNG 133

  Fly   133 SLNHLLHLQSVYELDSNSLSLGVVNGFKLG----SSMSWGDCLEVAR----KSDFPVARFWLESA 189
            :...||.||..|:||:.::|.|.:.|...|    |:::..||.|:.:    .:|:.....|:..|
Zfish   134 AAKALLRLQDTYKLDTQTISSGDLPGVNTGLPYKSTLTVEDCFELGKIAYSDADYYHTELWMAQA 198

  Fly   190 LEKLPSASENSTESQRERESGRVHILEATLNIEYRAGELSRALATAEELLLLLPMNQ-------- 246
            |::|....|:|.|.        ...|:......|:.|||.|||...:.||.:.|.:|
Zfish   199 LKQLDEGEESSVEI--------ATALDYLSYSVYQQGELERALEYTKRLLTVEPEHQRALGNLKY 255

  Fly   247 -GIQKAK-RKIEKAMAKKELPKGRGQKSKAKKQISKSTEQLLIEEICRGAKQQVTTGSRFNH--C 307
             ..|.|| :|.||..:.||..|...:.|..||:.  ..|:...|::|||...::|. .|..|  |
Zfish   256 FDYQLAKQKKAEKEQSTKEESKKEQETSDGKKEY--LPEKRKYEKLCRGEGLKMTP-RRQKHLFC 317

  Fly   308 Q-LDGS-SPWLLLQPSRLEPVSSDPYIVLHHDVLTPKESNELLQLIDE-------EEDTKGV--- 360
            : .:|: .|:..:.|.:.|.....|.|:.:|:::|.:|..::.:|...       .....||
Zfish   318 RYFNGNRHPFYTIGPVKQEDEWDRPRIIRYHEIITEQEIEKIKELSKPRLRRATISNPITGVLET 382

  Fly   361 ------------SYQSLKLSKLAQKKLGRISRLLGLEILELDPWTGRRHG-------HEHITKLE 406
                        :|:...:.::.|    ||..:.||.:...:......:|       |....:.:
Zfish   383 AHYRISKSAWLAAYEHPVVDRINQ----RIEDITGLNVKTAEELQVANYGVGGQYEPHFDFGRKD 443

  Fly   407 HSSELK------HVARLMLNLQAPGMGGAVVFPQLELAVNVPRGSLLHWRTRFAGGSSSEWDYRS 465
            .....|      .:|..:..:.....|||.|||::..||...:|:.:.|...|..|   |.||.:
Zfish   444 EPDAFKELGTGNRIATWLFYMSDVAAGGATVFPEVGAAVKPLKGTAVFWYNLFPSG---EGDYST 505

  Fly   466 GQAICPVLLG 475
            ..|.||||:|
Zfish   506 RHAACPVLVG 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31371	NP_733375.2	P4Ha_N	30..156	CDD:285528	36/126 (29%)
p4ha1a	XP_009304776.1	P4Ha_N	28..157	CDD:285528	36/128 (28%)
		TPR repeat	172..207	CDD:276809	8/34 (24%)
		TPR repeat	212..242	CDD:276809	10/37 (27%)
		Fis1	218..262	CDD:304536	12/43 (28%)
		P4Hc	352..525	CDD:214780	36/171 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583429
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391515at2759
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850